Index by author
Elbe, P.
- ADULT BRAINOpen AccessRestriction Spectrum Imaging Improves Risk Stratification in Patients with GlioblastomaA.P. Krishnan, R. Karunamuni, K.M. Leyden, T.M. Seibert, R.L. Delfanti, J.M. Kuperman, H. Bartsch, P. Elbe, A. Srikant, A.M. Dale, S. Kesari, D.E. Piccioni, J.A. Hattangadi-Gluth, N. Farid, C.R. McDonald and N.S. WhiteAmerican Journal of Neuroradiology May 2017, 38 (5) 882-889; DOI: https://doi.org/10.3174/ajnr.A5099
Elkind, M.S.V.
- ADULT BRAINOpen AccessBrain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan StudyJ. Gutierrez, M.S.V. Elkind, C. Dong, M. Di Tullio, T. Rundek, R.L. Sacco and C.B. WrightAmerican Journal of Neuroradiology May 2017, 38 (5) 862-867; DOI: https://doi.org/10.3174/ajnr.A5129
Englander, Z.K.
- EDITOR'S CHOICEADULT BRAINYou have accessA Multiparametric Model for Mapping Cellularity in Glioblastoma Using Radiographically Localized BiopsiesP.D. Chang, H.R. Malone, S.G. Bowden, D.S. Chow, B.J.A. Gill, T.H. Ung, J. Samanamud, Z.K. Englander, A.M. Sonabend, S.A. Sheth, G.M. McKhann, M.B. Sisti, L.H. Schwartz, A. Lignelli, J. Grinband, J.N. Bruce and P. CanollAmerican Journal of Neuroradiology May 2017, 38 (5) 890-898; DOI: https://doi.org/10.3174/ajnr.A5112
Ninety-one localized biopsies were obtained from 36 patients with glioblastoma. Signal intensities corresponding to these samples were derived from T1-postcontrast subtraction, T2-FLAIR, and ADC sequences by using an automated coregistration algorithm. Cell density was calculated for each specimen by using an automated cell-counting algorithm. T2-FLAIR and ADC sequences were inversely correlated with cell density. T1-postcontrast subtraction was directly correlated with cell density. The authors conclude that the model illustrates a quantitative and significant relationship between MR signal and cell density. Applying this relationship over the entire tumor volume allows mapping of the intratumoral heterogeneity for both enhancing core and nonenhancing margins.