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<meta name="DC.Title" content="MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants" />
<meta name="DC.Identifier" content="10.3174/ajnr.A6666" />
<meta name="DC.Date" content="2020-08-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2020 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Brain MR imaging at term-equivalent age is a useful tool to define brain injury in preterm infants. We report pragmatic clinical radiological assessment of images from a large unselected cohort of preterm infants imaged at term and document the spectrum and frequency of acquired brain lesions and their relation to outcomes at 20 months.

MATERIALS AND METHODS: Infants born at &lt;33 weeks’ gestation were recruited from South and North West London neonatal units and imaged in a single center at 3T at term-equivalent age. At 20 months’ corrected age, they were invited for neurodevelopmental assessment. The frequency of acquired brain lesions and the sensitivity, specificity, and negative and positive predictive values for motor, cognitive, and language outcomes were calculated, and corpus callosal thinning and ventricular dilation were qualitatively assessed.

RESULTS: Five hundred four infants underwent 3T MR imaging at term-equivalent age; 477 attended for assessment. Seventy-six percent of infants had acquired lesions, which included periventricular leukomalacia, hemorrhagic parenchymal infarction, germinal matrix–intraventricular hemorrhage, punctate white matter lesions, cerebellar hemorrhage, and subependymal cysts. All infants with periventricular leukomalacia, and 60% of those with hemorrhagic parenchymal infarction had abnormal motor outcomes. Routine 3T MR imaging of the brain at term-equivalent age in an unselected preterm population that demonstrates no focal lesion is 45% sensitive and 61% specific for normal neurodevelopment at 20 months and 17% sensitive and 94% specific for a normal motor outcome.

CONCLUSIONS: Acquired brain lesions are common in preterm infants routinely imaged at term-equivalent age, but not all predict an adverse neurodevelopmental outcome.

BSID-III
:   Bayley Scales of Infant Development, Version III
GMFCS
:   Gross Motor Function Classification System
GMH–IVH
:   germinal matrix hemorrhage–intraventricular hemorrhage
HPI
:   hemorrhagic parenchymal infarction
IMD
:   index of multiple deprivation
M-CHAT
:   Modified Checklist for Autism in Toddlers
PLIC
:   posterior limb of the internal capsule
PMA
:   postmenstrual age
PVL
:   periventricular leukomalacia
PWML
:   punctate white matter lesions
TEA
:   term-equivalent age" />
<meta name="DC.Contributor" content="S. Arulkumaran" />
<meta name="DC.Contributor" content="N. Tusor" />
<meta name="DC.Contributor" content="A. Chew" />
<meta name="DC.Contributor" content="S. Falconer" />
<meta name="DC.Contributor" content="N. Kennea" />
<meta name="DC.Contributor" content="P. Nongena" />
<meta name="DC.Contributor" content="J.V. Hajnal" />
<meta name="DC.Contributor" content="S.J. Counsell" />
<meta name="DC.Contributor" content="M.A. Rutherford" />
<meta name="DC.Contributor" content="A.D. Edwards" />
<meta name="article:published_time" content="2020-08-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Brain MR imaging at term-equivalent age is a useful tool to define brain injury in preterm infants. We report pragmatic clinical radiological assessment of images from a large unselected cohort of preterm infants imaged at term and document the spectrum and frequency of acquired brain lesions and their relation to outcomes at 20 months.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Infants born at &amp;lt;33 weeks’ gestation were recruited from South and North West London neonatal units and imaged in a single center at 3T at term-equivalent age. At 20 months’ corrected age, they were invited for neurodevelopmental assessment. The frequency of acquired brain lesions and the sensitivity, specificity, and negative and positive predictive values for motor, cognitive, and language outcomes were calculated, and corpus callosal thinning and ventricular dilation were qualitatively assessed.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Five hundred four infants underwent 3T MR imaging at term-equivalent age; 477 attended for assessment. Seventy-six percent of infants had acquired lesions, which included periventricular leukomalacia, hemorrhagic parenchymal infarction, germinal matrix–intraventricular hemorrhage, punctate white matter lesions, cerebellar hemorrhage, and subependymal cysts. All infants with periventricular leukomalacia, and 60% of those with hemorrhagic parenchymal infarction had abnormal motor outcomes. Routine 3T MR imaging of the brain at term-equivalent age in an unselected preterm population that demonstrates no focal lesion is 45% sensitive and 61% specific for normal neurodevelopment at 20 months and 17% sensitive and 94% specific for a normal motor outcome.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Acquired brain lesions are common in preterm infants routinely imaged at term-equivalent age, but not all predict an adverse neurodevelopmental outcome.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author" content="S. Arulkumaran" />
<meta name="citation_author_institution" content="aFrom the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK" />
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<meta name="twitter:title" content="MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Brain MR imaging at term-equivalent age is a useful tool to define brain injury in preterm infants. We report pragmatic clinical radiological assessment of images from a large unselected cohort of preterm infants imaged at term and document the spectrum and frequency of acquired brain lesions and their relation to outcomes at 20 months.

MATERIALS AND METHODS: Infants born at &lt;33 weeks’ gestation were recruited from South and North West London neonatal units and imaged in a single center at 3T at term-equivalent age. At 20 months’ corrected age, they were invited for neurodevelopmental assessment. The frequency of acquired brain lesions and the sensitivity, specificity, and negative and positive predictive values for motor, cognitive, and language outcomes were calculated, and corpus callosal thinning and ventricular dilation were qualitatively assessed.

RESULTS: Five hundred four infants underwent 3T MR imaging at term-equivalent age; 477 attended for assessment. Seventy-six percent of infants had acquired lesions, which included periventricular leukomalacia, hemorrhagic parenchymal infarction, germinal matrix–intraventricular hemorrhage, punctate white matter lesions, cerebellar hemorrhage, and subependymal cysts. All infants with periventricular leukomalacia, and 60% of those with hemorrhagic parenchymal infarction had abnormal motor outcomes. Routine 3T MR imaging of the brain at term-equivalent age in an unselected preterm population that demonstrates no focal lesion is 45% sensitive and 61% specific for normal neurodevelopment at 20 months and 17% sensitive and 94% specific for a normal motor outcome.

CONCLUSIONS: Acquired brain lesions are common in preterm infants routinely imaged at term-equivalent age, but not all predict an adverse neurodevelopmental outcome.

BSID-III
:   Bayley Scales of Infant Development, Version III
GMFCS
:   Gross Motor Function Classification System
GMH–IVH
:   germinal matrix hemorrhage–intraventricular hemorrhage
HPI
:   hemorrhagic parenchymal infarction
IMD
:   index of multiple deprivation
M-CHAT
:   Modified Checklist for Autism in Toddlers
PLIC
:   posterior limb of the internal capsule
PMA
:   postmenstrual age
PVL
:   periventricular leukomalacia
PWML
:   punctate white matter lesions
TEA
:   term-equivalent age" />
<meta name="og-title" property="og:title" content="MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/41/8/1509" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Brain MR imaging at term-equivalent age is a useful tool to define brain injury in preterm infants. We report pragmatic clinical radiological assessment of images from a large unselected cohort of preterm infants imaged at term and document the spectrum and frequency of acquired brain lesions and their relation to outcomes at 20 months.

MATERIALS AND METHODS: Infants born at &lt;33 weeks’ gestation were recruited from South and North West London neonatal units and imaged in a single center at 3T at term-equivalent age. At 20 months’ corrected age, they were invited for neurodevelopmental assessment. The frequency of acquired brain lesions and the sensitivity, specificity, and negative and positive predictive values for motor, cognitive, and language outcomes were calculated, and corpus callosal thinning and ventricular dilation were qualitatively assessed.

RESULTS: Five hundred four infants underwent 3T MR imaging at term-equivalent age; 477 attended for assessment. Seventy-six percent of infants had acquired lesions, which included periventricular leukomalacia, hemorrhagic parenchymal infarction, germinal matrix–intraventricular hemorrhage, punctate white matter lesions, cerebellar hemorrhage, and subependymal cysts. All infants with periventricular leukomalacia, and 60% of those with hemorrhagic parenchymal infarction had abnormal motor outcomes. Routine 3T MR imaging of the brain at term-equivalent age in an unselected preterm population that demonstrates no focal lesion is 45% sensitive and 61% specific for normal neurodevelopment at 20 months and 17% sensitive and 94% specific for a normal motor outcome.

CONCLUSIONS: Acquired brain lesions are common in preterm infants routinely imaged at term-equivalent age, but not all predict an adverse neurodevelopmental outcome.

BSID-III
:   Bayley Scales of Infant Development, Version III
GMFCS
:   Gross Motor Function Classification System
GMH–IVH
:   germinal matrix hemorrhage–intraventricular hemorrhage
HPI
:   hemorrhagic parenchymal infarction
IMD
:   index of multiple deprivation
M-CHAT
:   Modified Checklist for Autism in Toddlers
PLIC
:   posterior limb of the internal capsule
PMA
:   postmenstrual age
PVL
:   periventricular leukomalacia
PWML
:   punctate white matter lesions
TEA
:   term-equivalent age" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node77337--5" data-node-nid="77337" id="top-node-77337--6517224913" data-pisa="ajnr;41/8/1509" data-pisa-master="ajnr;41/8/1509" data-apath="/ajnr/41/8/1509.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S. Arulkumaran</span>, <span class="highwire-citation-author" data-delta="1">N. Tusor</span>, <span class="highwire-citation-author" data-delta="2">A. Chew</span>, <span class="highwire-citation-author" data-delta="3">S. Falconer</span>, <span class="highwire-citation-author" data-delta="4">N. Kennea</span>, <span class="highwire-citation-author" data-delta="5">P. Nongena</span>, <span class="highwire-citation-author" data-delta="6">J.V. Hajnal</span>, <span class="highwire-citation-author" data-delta="7">S.J. Counsell</span>, <span class="highwire-citation-author" data-delta="8">M.A. Rutherford</span> and <span class="highwire-citation-author" data-delta="9">A.D. Edwards</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2020,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">41 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1509-1516; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A6666 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-77337--6517224913" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S. Arulkumaran </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BArulkumaran%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Arulkumaran%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BArulkumaran%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4510-1767" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Arulkumaran</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">N. Tusor </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BTusor%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tusor%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BTusor%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3664-7397" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Tusor</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A. Chew </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BChew%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chew%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BChew%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4344-2015" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Chew</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">S. Falconer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BFalconer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Falconer%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BFalconer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3359-4736" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Falconer</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">N. Kennea </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Neonatal Unit (N.K.), St. George’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BKennea%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kennea%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BKennea%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6150-2686" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Kennea</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">P. Nongena </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Clinical Sciences (P.N.), Imperial College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BNongena%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nongena%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AP.%2BNongena%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9256-270X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for P. Nongena</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">J.V. Hajnal </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.V.%2BHajnal%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hajnal%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.V.%2BHajnal%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2690-5495" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.V. Hajnal</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">S.J. Counsell </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.J.%2BCounsell%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Counsell%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.J.%2BCounsell%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8033-5673" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.J. Counsell</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">M.A. Rutherford </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.A.%2BRutherford%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rutherford%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.A.%2BRutherford%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3361-1337" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.A. Rutherford</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">A.D. Edwards </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Centre for the Developing Brain (S.A., N.T., A.C., S.F., J.V.H., S.J.C., M.A.R., A.D.E.), School of Biomedical engineering and Imaging Sciences, King’s College London and Evelina London Children’s Hospital, London, UK</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.D.%2BEdwards%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Edwards%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.D.%2BEdwards%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4801-7066" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.D. 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      <div class="highwire-cite-title">MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Arulkumaran</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Tusor</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Chew</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Falconer</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kennea</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Nongena</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.V.</span> <span class="nlm-surname">Hajnal</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">S.J.</span> <span class="nlm-surname">Counsell</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.A.</span> <span class="nlm-surname">Rutherford</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">A.D.</span> <span class="nlm-surname">Edwards</span></span></span></div>
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Arulkumaran</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Tusor</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Chew</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Falconer</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kennea</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Nongena</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.V.</span> <span class="nlm-surname">Hajnal</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">S.J.</span> <span class="nlm-surname">Counsell</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.A.</span> <span class="nlm-surname">Rutherford</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">A.D.</span> <span class="nlm-surname">Edwards</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2020, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">41 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1509-1516; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A6666 </span></div>
  
  
  
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