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<meta name="DC.Title" content="Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A6709" />
<meta name="DC.Date" content="2020-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Anisotropy is a good indicator of white matter fascicle macrostructure and organization but the interpretation of its changes with age remains difficult. The increase of WM fascicle fractional anisotropy with time and its relationship with WM fascicle volume have never been examined during childhood. We studied the maturation of associative WM fascicles during childhood using MR imaging–based DTI. We explored whether the fractional anisotropy increase of the main WM fascicles persists beyond the period of brain growth and is related to WM fascicle volume increase.

MATERIALS AND METHODS: In a series of 25 healthy children, the fractional anisotropy and volume of 15 associative WM fascicles were calculated. Several regression linear mixed models were used to study maturation parameters (fractional anisotropy, volume, and total telencephalon volume) considered as dependent variables, while age and sex were independent variables (the variable identifying the different WM fascicles was considered as a repeated measure).

RESULTS: In children older than 8 years of age, WM fascicle fractional anisotropy increased with age ( P value = .045) but not its volume ( P value = .7) or the telencephalon volume ( P value = .16). The time course of WM fascicle fractional anisotropy and volume suggested that each WM fascicle might follow a specific pattern of maturation.

CONCLUSIONS: The fractional anisotropy increase of several WM fascicles after 8 years of age may not result from an increase in WM fascicle volume. It might be the consequence of other developmental processes such as myelination.

FA
:   fractional anisotropy" />
<meta name="DC.Contributor" content="G. Coll" />
<meta name="DC.Contributor" content="E. de Schlichting" />
<meta name="DC.Contributor" content="L. Sakka" />
<meta name="DC.Contributor" content="J.-M. Garcier" />
<meta name="DC.Contributor" content="H. Peyre" />
<meta name="DC.Contributor" content="J.-J. Lemaire" />
<meta name="article:published_time" content="2020-09-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Anisotropy is a good indicator of white matter fascicle macrostructure and organization but the interpretation of its changes with age remains difficult. The increase of WM fascicle fractional anisotropy with time and its relationship with WM fascicle volume have never been examined during childhood. We studied the maturation of associative WM fascicles during childhood using MR imaging–based DTI. We explored whether the fractional anisotropy increase of the main WM fascicles persists beyond the period of brain growth and is related to WM fascicle volume increase.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;In a series of 25 healthy children, the fractional anisotropy and volume of 15 associative WM fascicles were calculated. Several regression linear mixed models were used to study maturation parameters (fractional anisotropy, volume, and total telencephalon volume) considered as dependent variables, while age and sex were independent variables (the variable identifying the different WM fascicles was considered as a repeated measure).&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;In children older than 8 years of age, WM fascicle fractional anisotropy increased with age (&lt;i&gt;P&lt;/i&gt; value = .045) but not its volume (&lt;i&gt;P&lt;/i&gt; value = .7) or the telencephalon volume (&lt;i&gt;P&lt;/i&gt; value = .16). The time course of WM fascicle fractional anisotropy and volume suggested that each WM fascicle might follow a specific pattern of maturation.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The fractional anisotropy increase of several WM fascicles after 8 years of age may not result from an increase in WM fascicle volume. It might be the consequence of other developmental processes such as myelination.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2020/09/01" />
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<meta name="citation_firstpage" content="1726" />
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<meta name="citation_author" content="G. Coll" />
<meta name="citation_author_institution" content="aService de Neurochirurgie (G.C.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France" />
<meta name="citation_author_institution" content="bCentre National de la Recherche Scientifique (G.C.), SIGMA Clermont, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, France" />
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<meta name="citation_author_institution" content="eLaboratoire d'anatomie et d'organogenèse, laboratoire de biophysique sensorielle (L.S.), NeuroDol, faculté de médecine, Université Clermont Auvergne, Clermont-Ferrand, France" />
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<meta name="citation_author_institution" content="gLaboratoire d'Anatomie et d'Organogenèse, Laboratoire de Biophysique Sensorielle (J.M.G.), NeuroDol, Faculté de Médecine, Université Clermont Auvergne, Clermont-Ferrand, France" />
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<meta name="twitter:title" content="Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Anisotropy is a good indicator of white matter fascicle macrostructure and organization but the interpretation of its changes with age remains difficult. The increase of WM fascicle fractional anisotropy with time and its relationship with WM fascicle volume have never been examined during childhood. We studied the maturation of associative WM fascicles during childhood using MR imaging–based DTI. We explored whether the fractional anisotropy increase of the main WM fascicles persists beyond the period of brain growth and is related to WM fascicle volume increase.

MATERIALS AND METHODS: In a series of 25 healthy children, the fractional anisotropy and volume of 15 associative WM fascicles were calculated. Several regression linear mixed models were used to study maturation parameters (fractional anisotropy, volume, and total telencephalon volume) considered as dependent variables, while age and sex were independent variables (the variable identifying the different WM fascicles was considered as a repeated measure).

RESULTS: In children older than 8 years of age, WM fascicle fractional anisotropy increased with age ( P value = .045) but not its volume ( P value = .7) or the telencephalon volume ( P value = .16). The time course of WM fascicle fractional anisotropy and volume suggested that each WM fascicle might follow a specific pattern of maturation.

CONCLUSIONS: The fractional anisotropy increase of several WM fascicles after 8 years of age may not result from an increase in WM fascicle volume. It might be the consequence of other developmental processes such as myelination.

FA
:   fractional anisotropy" />
<meta name="og-title" property="og:title" content="Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Anisotropy is a good indicator of white matter fascicle macrostructure and organization but the interpretation of its changes with age remains difficult. The increase of WM fascicle fractional anisotropy with time and its relationship with WM fascicle volume have never been examined during childhood. We studied the maturation of associative WM fascicles during childhood using MR imaging–based DTI. We explored whether the fractional anisotropy increase of the main WM fascicles persists beyond the period of brain growth and is related to WM fascicle volume increase.

MATERIALS AND METHODS: In a series of 25 healthy children, the fractional anisotropy and volume of 15 associative WM fascicles were calculated. Several regression linear mixed models were used to study maturation parameters (fractional anisotropy, volume, and total telencephalon volume) considered as dependent variables, while age and sex were independent variables (the variable identifying the different WM fascicles was considered as a repeated measure).

RESULTS: In children older than 8 years of age, WM fascicle fractional anisotropy increased with age ( P value = .045) but not its volume ( P value = .7) or the telencephalon volume ( P value = .16). The time course of WM fascicle fractional anisotropy and volume suggested that each WM fascicle might follow a specific pattern of maturation.

CONCLUSIONS: The fractional anisotropy increase of several WM fascicles after 8 years of age may not result from an increase in WM fascicle volume. It might be the consequence of other developmental processes such as myelination.

FA
:   fractional anisotropy" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node78259--5" data-node-nid="78259" id="top-node-78259--61250997286" data-pisa="ajnr;41/9/1726" data-pisa-master="ajnr;ajnr.A6709" data-apath="/ajnr/41/9/1726.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">G. Coll</span>, <span class="highwire-citation-author" data-delta="1">E. de Schlichting</span>, <span class="highwire-citation-author" data-delta="2">L. Sakka</span>, <span class="highwire-citation-author" data-delta="3">J.-M. Garcier</span>, <span class="highwire-citation-author" data-delta="4">H. Peyre</span> and <span class="highwire-citation-author" data-delta="5">J.-J. Lemaire</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2020,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">41 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1726-1732; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A6709 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-78259--61250997286" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">G. Coll </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Service de Neurochirurgie (G.C.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Centre National de la Recherche Scientifique (G.C.), SIGMA Clermont, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BColl%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Coll%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BColl%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6117-3939" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Coll</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E. de Schlichting </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Service de Neurochirurgie (E.d.S.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2Bde%2BSchlichting%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=de%20Schlichting%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2Bde%2BSchlichting%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1962-5647" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. de Schlichting</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">L. Sakka </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Service de Neurochirurgie (L.S.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Laboratoire d'anatomie et d'organogenèse, laboratoire de biophysique sensorielle (L.S.), NeuroDol, faculté de médecine, Université Clermont Auvergne, Clermont-Ferrand, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BSakka%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sakka%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AL.%2BSakka%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1560-2875" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for L. Sakka</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J.-M. Garcier </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Service de Radiologie Pédiatrique (J.M.-G.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Laboratoire d'Anatomie et d'Organogenèse, Laboratoire de Biophysique Sensorielle (J.M.G.), NeuroDol, Faculté de Médecine, Université Clermont Auvergne, Clermont-Ferrand, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.-M.%2BGarcier%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Garcier%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.-M.%2BGarcier%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2648-2920" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.-M. Garcier</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">H. Peyre </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Service de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Robert Debré (H.P.), Assistance Publique–Hôpitaux de Paris, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BPeyre%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Peyre%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BPeyre%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8757-0783" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Peyre</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">J.-J. Lemaire </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Service de Neurochirurgie (J.-J.L.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France</div><div class='author-affiliation'><span class='nlm-sup'>j</span>Centre National de la Recherche Scientifique (J.-J.L.), SIGMA Clermont, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, France.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.-J.%2BLemaire%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lemaire%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.-J.%2BLemaire%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4395-5328" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.-J. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><div id="sec-1" class="subsection"><p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> Anisotropy is a good indicator of white matter fascicle macrostructure and organization but the interpretation of its changes with age remains difficult. The increase of WM fascicle fractional anisotropy with time and its relationship with WM fascicle volume have never been examined during childhood. We studied the maturation of associative WM fascicles during childhood using MR imaging–based DTI. We explored whether the fractional anisotropy increase of the main WM fascicles persists beyond the period of brain growth and is related to WM fascicle volume increase.</p></div><div id="sec-2" class="subsection"><p id="p-2"><strong>MATERIALS AND METHODS:</strong> In a series of 25 healthy children, the fractional anisotropy and volume of 15 associative WM fascicles were calculated. Several regression linear mixed models were used to study maturation parameters (fractional anisotropy, volume, and total telencephalon volume) considered as dependent variables, while age and sex were independent variables (the variable identifying the different WM fascicles was considered as a repeated measure).</p></div><div id="sec-3" class="subsection"><p id="p-3"><strong>RESULTS:</strong> In children older than 8 years of age, WM fascicle fractional anisotropy increased with age (<em>P</em> value = .045) but not its volume (<em>P</em> value = .7) or the telencephalon volume (<em>P</em> value = .16). The time course of WM fascicle fractional anisotropy and volume suggested that each WM fascicle might follow a specific pattern of maturation.</p></div><div id="sec-4" class="subsection"><p id="p-4"><strong>CONCLUSIONS:</strong> The fractional anisotropy increase of several WM fascicles after 8 years of age may not result from an increase in WM fascicle volume. It might be the consequence of other developmental processes such as myelination.</p></div></div><div class="section glossary" id="glossary-1"><h2 class="">ABBREVIATION:</h2><dl id="def-list-1"><dt id="def-item-1">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2020 by American Journal of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/41/9/1726.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 41</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2020 </div></div>
      
      
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Coll</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">E.</span> <span class="nlm-surname">de Schlichting</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Sakka</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.-M.</span> <span class="nlm-surname">Garcier</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Peyre</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.-J.</span> <span class="nlm-surname">Lemaire</span></span></span></div>
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Coll</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">E.</span> <span class="nlm-surname">de Schlichting</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Sakka</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.-M.</span> <span class="nlm-surname">Garcier</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Peyre</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.-J.</span> <span class="nlm-surname">Lemaire</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2020, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">41 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1726-1732; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A6709 </span></div>
  
  
  
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