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    Thalamic Anisotropy and Functional Disability | American Journal of Neuroradiology  
    


















    


























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Article CommentaryBRAIN

  
      

  
      
Thalamic Anisotropy and Functional Disability
  
    	
O. Rapalino

  
    	
American Journal of Neuroradiology August 2009,  30 (7) 1387; DOI: https://doi.org/10.3174/ajnr.A1706 

  
  
  



  


  
  



  
      
  
  

    
The thalami are highly organized complexes of gray matter nuclei and white matter tracts, widely interconnected with the cerebral cortex and other gray matter structures, that play a central role in sensory relay and limbic and other important functional systems. Although the thalami predominantly contain gray matter nuclei, there are many myelinated and unmyelinated tracts in the thalami, many of them belonging to projection systems and intrathalamic circuits.1 The thalamic nuclear organization is compartmentalized by bands of white matter tracts (internal and external medullary laminae) traversing the thalami and separating different nuclear groups.1,2 The significant number of axonal tracts combined with the described laminated and compartmentalized cytoarchitectural organization of the thalami are likely responsible for the observed anisotropy in diffusion tensor imaging studies.3,4
Because of the central role of the thalami in many physiologic systems, it is not surprising to find an increasing number of studies using a variety of different MR imaging modalities (conventional volumetric assessment, magnetization transfer, MR spectroscopy, and diffusion tensor imaging) that demonstrate the central role of thalamic involvement in the pathophysiology of various pathologic conditions (including multiple sclerosis, schizophrenia, and head trauma, to name a few).5–7 In particular, thalamic involvement is becoming increasingly recognized as a significant step in the development of clinical disability and memory impairment in multiple sclerosis.8 Tovar-Moll et al9 in an article published in the current issue of the American Journal of Neuroradiology demonstrate thalamic abnormalities in diffusion tensor metrics that correlate with clinical disability scores, in keeping with similar studies published on the subject.10,11 Most interesting, Tovar-Moll et al reported increased fractional anisotropy (FA) and mean diffusivity (MD) values in the thalamus in comparison with matched controls. The significance of these tensor measurements is clearly a matter for further research to elucidate whether the increased FA values are attributable to neural plasticity changes,11 whereas the increased MD values reflect the presence of demyelination and neuronal damage (direct or indirect due to wallerian degeneration).
Overall, the article by Tovar-Moll et al9 highlights the potential of diffusion tensor imaging techniques in the evaluation of gray matter pathology, particularly of the thalamus, and contributes to our understanding of the pathophysiology of multiple sclerosis.
References
  1. Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science. 4th ed. New York: McGraw-Hill, Health Professions Division;2000 :xli ,1414
  2. Berezhnaya LA. Primary structural modules of the dorsal nuclei of the thalamus and motor cortex in humans. Neurosci Behav Physiol 2007;37:89–95
  3. Duan Y, Li X, Xi Y. Thalamus segmentation from diffusion tensor magnetic resonance imaging. Int J Biomed Imaging 2007;2007:90216
  4. DaSilva AF, Tuch DS, Wiegell MR, et al. A primer on diffusion tensor imaging of anatomical substructures. Neurosurg Focus 2003;15:E4
  5. Tao G, Datta S, Nelson F, et al. Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry. J Neurol Sci 2009  Jan 23. [Epub ahead of print]
  6. Tollard E, Galanaud D, Perlbarg V, et al. Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: preliminary results. Crit Care Med 2009;37:1448–55
  7. Qiu A, Zhong J, Graham S, et al. Combined analyses of thalamic volume, shape and white matter integrity in first-episode schizophrenia. Neuroimage 2009  Apr 16. [Epub ahead of print]
  8. Houtchens MK, Benedict RH, Killiany R, et al. Thalamic atrophy and cognition in multiple sclerosis. Neurology 2007;69:1213–23
  9. Tovar-Moll F, Evangelou TE, Chiu AW, et al. Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: a diffusion tensor imaging study at 3T. AJNR Am J Neuroradiol 2009;30:1381–87
  10. Bodini B, Khaleeli Z, Cerciqnani M, et al. Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM. Hum Brain Mapp 2009  Jan 26. [Epub ahead of print]
  11. Audoin B, Guye M, Reuter F, et al. Structure of WM bundles constituting the working memory system in early multiple sclerosis: a quantitative DTI tractography study. Neuroimage 2007;36:1324–30. Epub 2007 Apr 27
  


  
  



  



    

  



  

                
    

      

  

    

  
      
  
  

    


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