1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [cd44b5f3-fc3a-42b9-9674-c7c0ef240443] => Array
        (
            [runtime-id] => cd44b5f3-fc3a-42b9-9674-c7c0ef240443
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [f381fd15-6fe1-42b5-853b-4b55a64ef314] => Array
                        (
                            [runtime-id] => f381fd15-6fe1-42b5-853b-4b55a64ef314
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [d9b46b52-e500-4626-9dd0-850c189c0446] => Array
        (
            [runtime-id] => d9b46b52-e500-4626-9dd0-850c189c0446
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [cef6cad4-5ca8-46d9-899a-95d6e53e8327] => Array
                        (
                            [runtime-id] => cef6cad4-5ca8-46d9-899a-95d6e53e8327
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [d9b46b52-e500-4626-9dd0-850c189c0446] => Array
        (
            [runtime-id] => d9b46b52-e500-4626-9dd0-850c189c0446
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [cef6cad4-5ca8-46d9-899a-95d6e53e8327] => Array
                        (
                            [runtime-id] => cef6cad4-5ca8-46d9-899a-95d6e53e8327
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [d9b46b52-e500-4626-9dd0-850c189c0446] => Array
        (
            [runtime-id] => d9b46b52-e500-4626-9dd0-850c189c0446
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [cef6cad4-5ca8-46d9-899a-95d6e53e8327] => Array
                        (
                            [runtime-id] => cef6cad4-5ca8-46d9-899a-95d6e53e8327
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [d9b46b52-e500-4626-9dd0-850c189c0446] => Array
        (
            [runtime-id] => d9b46b52-e500-4626-9dd0-850c189c0446
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [cef6cad4-5ca8-46d9-899a-95d6e53e8327] => Array
                        (
                            [runtime-id] => cef6cad4-5ca8-46d9-899a-95d6e53e8327
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [d9b46b52-e500-4626-9dd0-850c189c0446] => Array
        (
            [runtime-id] => d9b46b52-e500-4626-9dd0-850c189c0446
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [cef6cad4-5ca8-46d9-899a-95d6e53e8327] => Array
                        (
                            [runtime-id] => cef6cad4-5ca8-46d9-899a-95d6e53e8327
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [1a5948ea-b6ec-4138-9f5a-594ecbac3ebf] => Array
        (
            [runtime-id] => 1a5948ea-b6ec-4138-9f5a-594ecbac3ebf
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [2eeb6a27-9fa3-4db8-9031-9ed110c1d9c5] => Array
                        (
                            [runtime-id] => 2eeb6a27-9fa3-4db8-9031-9ed110c1d9c5
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;57be28853878e7eda6f0f4858a93202ae2fe8a67
                )

        )

)


  
    











    Acute Bilateral Deafness as the First Symptom of Wernicke Encephalopathy | American Journal of Neuroradiology  
    


















    


























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      



          


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

  

    

  
      
  
  

    

  
  
      
LetterLetter

  
      

  
      
Acute Bilateral Deafness as the First Symptom of Wernicke Encephalopathy
  
    	
S.-Q. Zhang and Y.-T. Guan

  
    	
American Journal of Neuroradiology March 2012,  33 (3) E44-E45; DOI: https://doi.org/10.3174/ajnr.A3040 

  
  
  



  


  
  



  
      
  
  

    
Wernicke encephalopathy is a syndrome that is caused by thiamine deficiency and characterized by the triad of ophthalmoplegia, ataxia, and confusion, with short-term memory loss. It typically begins with ataxia, followed in a few days or weeks by mental confusion. Additionally, there may be a simultaneous onset of ataxia, nystagmus, and ophthalmoplegia with or without confusion. Less often, 1 component of the triad may be the sole manifestation.1 The incidence of Wernicke encephalopathy has fallen significantly in the alcoholic population; however, it is being recognized with increasing frequency among nonalcoholic patients in a variety of clinical settings, mainly iatrogenic ones. Bilateral blindness has been observed to occur during the course or even as the initial symptom,2⇓–4 but bilateral deafness has rarely been reported.5 Here, we report a patient whose first symptom was acute bilateral deafness during the treatment of acute pancreatitis.
A 23-year-old man presented at the emergency department with acute abdominal pain. He had no history of alcoholism. He was quickly diagnosed with acute pancreatitis, and his diet was then strictly limited for approximately 1 month. On day 31, his parents found he did not answer their questions unless they spoke very loudly. Shortly after, he said the world became “completely silent, ” though others were talking. This symptom lasted for 2 days, and then he felt severe tinnitus in both ears. On the morning of day 33, he felt diplopia, but he still had normal orientation. By the afternoon of that day, the patient became confused and spoke in an unintelligible manner, prompting a neurologist consultation. Neurologic examination revealed a global confusional state. He was apathetic, inattentive, and indifferent to his surroundings. Spontaneous speech was minimal, and many questions were left unanswered. At times, the patient drifted off to sleep, though he could be aroused without difficulty.
The neuro-ophthalmologic picture was complex: He presented prominent exotropia due to severe bilateral oculomotor palsy and spontaneous vertical or sometimes rotational nystagmus. His pupils were large and sluggish in responding to light. Additionally, he presented with cerebellar ataxia with bilateral intention tremor on both arms and legs, whereas there was no rest tremor. He could not stand upright, with eyes open or shut. The bilateral Babinski sign was absent. Blood examination showed normal kidney function and normal levels of the following: liver enzyme, serum glucose, inflammatory markers, and electrolytes. Serum thiamine could not be determined owing to a lack of techniques and instruments at the hospital. MR imaging of his brain demonstrated signal-intensity changes in the bilateral inferior colliculi, superior colliculi, bilateral posteromedial thalamus, and bilateral inferior cerebellar peduncles on diffusion-weighted or T2-weighted imaging (Fig 1).
Fig 1.
Fig 1. 

Brain MR diffusion-weighted imaging demonstrates symmetric hyperintensities in the bilateral inferior colliculi (A and B), posteromedial thalamus (D and E), and mammillary bodies (C). MR imaging with T2-weighting demonstrates hyperintensity in bilateral inferior cerebellar peduncles (F).
In view of his dietary limitation due to pancreatitis, diagnosis of Wernicke encephalopathy was considered, and a daily dose of 200-mg thiamine was empirically administered intravenously and continued during the next weeks. Two days after treatment, his symptoms (including deafness, diplopia, and mental disturbance) began to ameliorate. One week later, his gait disorder improved steadily. He was discharged from the emergency department after 3 weeks of thiamine injection and continued to take an oral thiamine tablet for a month.
To our knowledge, this is a rare case of Wernicke encephalopathy that began with bilateral deafness. As shown in Fig 1, there are obvious abnormal signals at the inferior colliculi of the midbrain on diffusion-weighted imaging, in addition to the abnormalities in the bilateral thalamus, inferior cerebellar peduncles, and mammillary bodies.
The daily thiamine requirement for healthy individuals is related to their carbonate intake and is between 1 and 2 mg per day. Because the body stores are only between 30 and 50 mg, it might be anticipated that this would be depleted in 4–6 weeks.6 A patient should be supplemented with thiamine if he or she cannot have a normal diet for longer than 1 week. This case is iatrogenic, and clinicians should know these important symptoms that herald Wernicke encephalopathy to avoid a potentially fatal result.
References
  1. 1.


    1. Ropper  AH, 
    2. Brown  RH
    . 
Adams and Victor's Principles of Neurology. 
8th ed. 
Columbus, Ohio: 
McGraw-Hill; 
2005:
984–
88

    

  2. 2.


    1. Tesfaye  S, 
    2. Achari  V, 
    3. Yang  YC, 
    4. et al
    . 
Pregnant, vomiting and going blind. 
Lancet 
1998;
352:
1594

    

  3. 3.


    1. Surges  R, 
    2. Beck  S, 
    3. Niesen  WD, 
    4. et al
    . 
Sudden bilateral blindness in Wernicke's encephalopathy: case report and review of the literature. 
J Neurol Sci 
2007;
260:
261–
64

    

  4. 4.


    1. Antunez  E, 
    2. Estruch  R, 
    3. Cardenal  C, 
    4. et al
    . 
Usefulness of CT and MR imaging in the diagnosis of acute Wernicke's encephalopathy. 
AJR Am J Roentgenol 
1998;
171:
1131–
37

    

  5. 5.


    1. Buscaglia  J, 
    2. Faris  J
    . 
Unsteady, unfocused, and unable to hear. 
Am J Med 
2005;
118:
1215–
17

    

  6. 6.


    1. Thomson  AD, 
    2. Marshall  EJ
    . 
The natural history and pathophysiology of Wernicke's encephalopathy and Korsakoff's psychosis. 
Alcohol Alcohol 
2006;
41:
151–
58. 
Epub 2005 Dec 29

    

  


  
  



  



    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement