Endovascular Treatment of Middle Cerebral Artery Aneurysms for 120 Nonselected Patients: A Prospective Cohort Study

Abstract

BACKGROUND AND PURPOSE: Multiple technologies have developed the endovascular approach to MCA aneurysms. We assess the safety and the efficacy of a systematic endovascular approach in nonselected patients with MCA aneurysms and determine predictors of treatment outcomes.

MATERIALS AND METHODS: We analyzed data collected between January 2007 and January 2012 in a prospective clinical registry. All patients with MCA aneurysms treated by means of the endovascular approach were included. A multivariate analysis was conducted to identify predictors of complications, recanalization, and outcome.

RESULTS: A total of 120 patients with 131 MCA aneurysms were included. Seventy-nine patients (65.8%) were treated electively and 41 (34.2%) in the setting of subarachnoid hemorrhage. Thirty-three of 131 aneurysms (25.2%) were treated with simple coiling, 79 aneurysms (60.3%) with balloon-assisted coiling, and 19 aneurysms (14.5%) with stent-assisted coiling. Complications occurred in 13.7% of patients. Stent-assisted coiling was significantly associated with more complications (P = .002; OR: 4.86; 95% CI, 1.60–14.72). At 1 month after treatment, both the permanent morbidity (mRS ≤2) and mortality rates were 3.3%, without any significant difference according to the endovascular techniques. Mean angiographic follow-up was 16.3 months. The rate of recanalization was 15.6% without a statistical difference, according to the technique. Larger aneurysms were a predictor of recanalization (P = .016; OR: 1.183; 95% CI, 1.02–1.36). Retreatment was performed in 10 of 131 aneurysms (7.6%).

CONCLUSIONS: Even though stent-assisted coiling significantly increases the risk of procedural complications, endovascular treatment of MCA aneurysms is safe, effective, and provides durable aneurysm closure in nonselected patients.

ABBREVIATIONS:

EVT: endovascular treatment
HH: Hunt and Hess

Endovascular treatment (EVT) of intracranial aneurysms is an established technique for both ruptured and unruptured aneurysms.^1,2 Nevertheless, many institutions still use surgical clipping (rather than coiling) as the first treatment for MCA aneurysms because they are accessible, even with complex anatomic features, which is not usually considered suitable for EVT with standard coiling.^3⇓–5 In a systematic review of endovascular series of MCA aneurysms, the rates of combined permanent morbidity and mortality were 5.1% and 6.0% for unruptured and ruptured aneurysms, respectively.⁶ However, most of these series were highly focused on selected patients.^7⇓⇓–10 To date, with the advent of new endovascular tools such as balloons and stents designed specifically for the intracranial circulation, MCA aneurysms can be managed by means of the endovascular approach. However, the safety and efficacy of EVT for all patients are not well known yet.

We assess the safety and the efficacy of a systematic endovascular approach in nonselected patients with MCA aneurysms in a prospective cohort. Predictors of complications, recanalization, and clinical outcome were determined.

Materials and Methods

Patients

Patients were identified by means of a prospective clinical registry of patients with intracranial aneurysms, which were treated at Dupuytren University Hospital, Limoges, France, from January 2007 to January 2012. Since January 2007, a systematic endovascular approach has been implemented in all patients with MCA aneurysms. Fusiform and dissecting aneurysms were excluded, as were aneurysms associated with brain arteriovenous malformations.

Endovascular Procedures

All procedures were performed with the use of general anesthesia and full anticoagulation (5000 IU of heparin given as an intravenous bolus injection). Anticoagulation was aimed at keeping the activated clotting time at 2 to 3 times above the normal value. We used bare platinum coils (GDC from Boston Scientific [Natick, Massachusetts]; Trufill from Codman & Shurtleff [Raynham, Massachusetts]; and MicroPlex from MicroVention [Tustin, California]).

In the setting of SAH, we used simple coiling or balloon-assisted techniques, considering the size of the neck and the need to protect MCA branches. We avoided the use of stents because of the risk of thrombosis. In the case of large hematomas requiring surgical evacuation, simple coiling was rapidly performed before surgery, without any aneurysm clipping.

In unruptured cases, simple coiling, double-catheter coiling,¹¹ balloon-assisted,^12,13 or stent-assisted coiling¹⁴ were used, depending on the neck size and aneurysm anatomy. In some cases of stent use, we used the balloon-assisted technique before inserting a stent because it appeared that the balloon technique obtained denser packing because of the inherent difficulty of crossing the stent struts in the first instance or in regaining access into the aneurysm. However, we considered it a stent group. In addition, in the case of simple coiling or balloon-assisted coiling for unruptured aneurysms, 250 mg of aspirin was given intravenously during the procedure. In the case of stent-assisted coiling, patients were given dual-antiplatelet therapy before surgery, which was continued for 12 months (75–150 mg clopidogrel, 160 mg aspirin daily).

Data Collection

We analyzed clinical and procedural data, considering patient age and sex, state of aneurysms, technique of EVT, technical complications, anatomic results, and patient evolution, 1 month after the procedure (C.M., R.R., B.G.). Technical complications were classified into thromboembolic events (clots near the neck of the aneurysm and/or in the distal branches), aneurysm rupture (extravasation of contrast media at the level of the aneurysm), and artery perforation (extravasation of contrast media at the level of artery). All technical complications were noted, whatever the clinical issue.

Angiographic images were acquired in the anteroposterior and lateral working projections before and immediately after treatment. The angiographic follow-up protocol consisted of the first angiogram performed 1–6 months after endovascular treatment and the second angiogram being performed 1 year after the first follow-up. A third angiogram was performed 2 years after the second follow-up.

Data Analysis

The location of the aneurysms was classified into 3 groups: proximal, bifurcation, and distal MCA aneurysms.¹⁵ Aneurysm dimensions were characterized by 3D images. The size of the aneurysm was defined on the basis of the greatest length of the aneurysmal sac. Angiographic occlusion assessment was classified by use of the simplified 3-point Raymond classification scale.¹⁶ A 2-point classification scale was also used: total occlusion (complete obliteration) and partial occlusion (residual neck or residual aneurysm). At follow-up, we considered an aneurysm recurrence when a recanalization was found in the neck of aneurysms completely occluded, regardless of how large. We also considered it as a recurrence when we observed that the neck remnant was increased in partly occluded aneurysms.

Clinical status was given at 1 month after the treatment by use of the mRS. Permanent morbidity was defined as an mRS of 3–5. If the preoperative score was 3–4, we defined permanent morbidity when it increased by 1 point.

Statistical Analysis

Statistical analysis was performed by use of the INSERM UMR-1094 (F.D.), with the use of SAS version 9.3 (SAS Institute, Cary, North Carolina). Sex, side (left/right), aneurysm status (ruptured/unruptured), wide neck (neck size ≥4 mm), and initial total occlusion rates were evaluated for statistical significance among 3 groups, by use of the Fisher exact test. Patient age, aneurysm size, neck size, and term of follow-up were compared by use of the Kruskal-Wallis U test. A stepwise multivariate logistic regression analysis was performed to control for potential confounders in aneurysm characteristics and in the occurrence of technical complications. Univariate analysis was conducted to evaluate the effect of treatment technique used on recurrence. Finally, a stepwise logistic regression analysis was used to determine factors associated with angiographic recurrence. The significance threshold was set at P = .05.

Results

Patients

One hundred twenty patients were included in this study (78 women and 42 men). The mean age was 53.2 years (range, 25–84 years), with no significant differences among the 3 groups (P = .904).

Initial Hunt and Hess (HH) grade of I was noted in 11 patients, HH grade of II in 10 patients, HH grade of III in 9 patients, HH grade of IV in 6 patients, and HH grade of V in 5 patients. Eleven patients had both ruptured and unruptured MCA aneurysms.

Aneurysms

One hundred thirty-one MCA aneurysms (41 ruptured, 90 unruptured) were involved. Mean aneurysm size was 6.4 mm (1.5–18.4 mm) and mean neck size was 4.1 mm (0.6–10.1 mm). Seventy (53.5%) of these had wide necks. Sixteen aneurysms (12.2%) were located on the main trunk of the artery (M1 segment), 112 (85.5%) were located at the first major bifurcation (M1-M2), and 3 (2.3%) were located beyond the major bifurcation (M2 segment). There was no significant difference of the mean size of sac and neck (Table 1).

View this table:

Table 1:

Characteristics of 131 aneurysms according to modality of endovascular treatment

Technique of Aneurysm Treatment

Coiling was performed in all patients with MCA aneurysms. Thirty-three aneurysms (25.2%) were treated with simple coiling (23 single-catheter and 10 double-catheter technique; Fig 1), 79 (60.3%) with balloon-assisted coiling (63 standard balloon, 12 round balloon, and 2 double-balloon technique) (Fig 2), and 19 (14.5%) with self-expandable stent-assisted coiling. Stents were delivered after coiling in 47.4% (n = 9; 5 Neuroform [Stryker Neurovascular, Kalamazoo, Michigan], 3 Enterprise [Codman & Shurtleff], 1 Wingspan [Stryker Neurovascular] stents), and before coiling in 52.6% (n = 10). We used the jailing technique (n = 8; 6 Neuroform and 2 Solitaire AB [Covidien, Irvine, California] stents), stent-jacking technique (n = 1; 1 Solitaire AB stent),¹⁷ and “Y” stent placement (n = 1; 1 Neuroform stent and 1 Enterprise stent) when stents were placed before coiling. One ruptured aneurysm (1 of 19, 5.3%) was treated with a rescue stent.

Fig 1.

A 68-year-old man with unruptured right MCA bifurcation aneurysm. A, 3D reconstruction after rotational angiogram of right internal carotid artery shows an 8-mm aneurysm (asterisk) with a 7-mm-wide neck, which can be considered unsuitable for EVT. The superior trunk (arrow) is incorporated into the aneurysm neck. B, Angiogram of right internal carotid artery shows coiling with double-catheter technique (arrow). C, Angiogram of right internal carotid artery directly after coiling demonstrates persistent opacification of the aneurysm neck. D, Angiogram of right internal carotid artery performed 16 months after coiling, showing complete aneurysm occlusion.

Fig 2.

A 54-year-old woman with unruptured left MCA bifurcation aneurysm. A, 3D reconstruction after rotational angiogram of left internal carotid artery shows a 7-mm aneurysm with a 4-mm-wide neck in the MCA bifurcation. Both MCA branches (arrows) are incorporated into the aneurysm neck. B, Angiogram of left internal carotid artery obtained during EVT with coils. The aneurysm is treated by means of the balloon-assisted technique by use of a round balloon (asterisk) to avoid coil protrusion (arrow). C, Angiogram of left internal carotid artery at the end of the procedure. There is persistent opacification of the aneurysm neck. D, Angiogram of left internal carotid artery at 23-month follow-up shows complete occlusion of the aneurysm and patent parent artery.

Complications

Table 2 reports complications during the procedure according to EVT technique. Eighteen complications (13.7%) occurred and included 10 aneurysm sac perforations (7.6%) (2 of 41 ruptured [4.9%] and 8 of 90 unruptured [8.9%] aneurysms), 2 distal parent artery perforations (1.5%) (1 of the 41 ruptured [2.4%] and 1 of 90 unruptured [1.1%] aneurysms), and 6 thromboembolic events (4.6%) (4 of 41 ruptured [9.7%] and 2 of 90 unruptured [2.2%] aneurysms). There were significantly more technical complications in the stent-assisted group (P = .005). In the multivariate analysis, stent assistance was the only statistically significant predictive risk factor for complications (P = .002; OR: 4.86; 95% CI, 1.60–14.72; Table 3).

View this table:

Table 2:

Complications according to modality of endovascular treatment

View this table:

Table 3:

Logistic regression analysis for complications

Clinical Status

Clinical status of patients at 1 month after treatment according to the technique is shown in Table 2. The overall 1-month mortality rate was 3.3% (n = 4; 2.5% in the unruptured group and 4.9% in the ruptured group). Three deaths were directly related to the procedure (2 aneurysm perforations, 1 thromboembolic event) and the other was caused by diffuse vasospasm in an initially ruptured aneurysm. The permanent morbidity rate at 1 month after the procedure was 3.3% (n = 4; 3.8% in the unruptured group and 2.4% in the ruptured group). One ischemic stroke occurred secondary to focal vasospasm in an initially ruptured aneurysm, 2 aneurysm perforations occurred, and 1 parent vessel perforation occurred. Statistically, a significant difference was not found, whatever the EVT technique. Overall permanent morbidity and mortality rates were 7.3% and 6.3% for unruptured and ruptured aneurysms, respectively.

Thirteen of 41 ruptured aneurysms (31.7%) had large hematomas; 8 needed surgical evacuation without clipping because the clinical status was serious. Four patients had a favorable outcome (mRS ≤2), 2 recorded mRS = 3, 1 had mRS = 4, and the others died. The dead patient had thromboembolic complications while being treated with 2 mg of abciximab (ReoPro). Among the other 5 patients who were treated without evacuation, 4 had a favorable outcome and the other died with severe vasospasm.

Initial Anatomic Results

Overall, we observed 83.2% with total occlusion, 16.0% with neck remnant, and 0.8% with sac remnant. In the simple coiling group, 78.8% (n = 26) of the aneurysms were totally occluded, 18.2% (n = 6) had a neck remnant, and 3.0% (n = 1) had a sac remnant. In the balloon group, 83.5% (n = 66) of the aneurysms were totally occluded and 16.5% (n = 13) had a neck remnant. In the stent group, 89.5% (n = 17) of the aneurysms were totally occluded and 10.5% (n = 2) had a neck remnant.

(Re)Bleeding/Retreatment

Of the 41 ruptured aneurysms treated, one (2.4%) bled again within the first 24 hours after treatment with a simple coiling technique, though the aneurysm was totally occluded.

During the follow-up period, retreatment was performed in 10 of 131 aneurysms (7.6%). Retreatment was performed ≤6 months after the initial treatment in 7 cases and >6 months after treatment in 3 cases. The size of the retreated aneurysms was ≤10 mm 6 cases and >10 mm in 4 cases. Retreated aneurysms had a neck size of <4 mm in 3 cases and ≥4 in 7 cases. Retreated aneurysms were initially treated by coiling in 3 cases, balloon-assisted coiling in 6 cases, and stent-assisted coiling in 1 case.

Anatomic Results at Follow-Up

Mean follow-up was 16.3 months (range, 4.2–28.4 months) and the overall recurrence rate was 17 (15.6%). There were 4 recurrences (17.4%) in the simple coiling group, 11 (15.5%) in the balloon-assisted group, and 2 (13.3%) in the stent-assisted group. Thirteen were observed for the first 6 months and the remainder in the second year after treatment. A larger aneurysm size was significantly associated with an increased recurrence rate (P = .016; OR: 1.183; 95% CI, 1.02–1.36; Table 4).

View this table:

Table 4:

Logistic regression analysis for factors affecting angiographic recurrence

Discussion

In this study, we assessed the safety and efficacy of an endovascular approach to MCA aneurysms in nonselected patients. All patients were consecutively included, not being selected by any criteria as long as they did not have fusiform or dissecting aneurysms, which minimized the effect of confounders and patient-selection bias. Even though MCA aneurysms are often considered unsuitable for endovascular therapy because of a wide neck and/or branches arising from the neck, these are now accessible because of the development of devices such as balloons and self-expanding stents. During the same time that the present study was conducted, no patients with MCA aneurysms were treated by clipping in our center. Only if the patient had symptomatic large intracerebral hematoma was a surgical evacuation conducted right after coiling. According to our results, endovascular treatment was feasible in all cases regardless of the aneurysm geometry or clinical status.

Complications occurred in 13.7% of patients in this series, causing death or permanent morbidity in 6.6%, which confirms the safety of the endovascular approach for treatment of MCA aneurysms. Of note, we used the number of patients involved as our denominator to figure out morbidity-mortality. The morbidity and mortality rates in our series are similar to those in previous EVT studies in selected cases such as the results by Suzuki et al⁸ and Vendrell et al.⁹ Meanwhile, morbidity-mortality of surgical clipping of MCA aneurysms is largely variable, ranging from 1.8–13.6%.^3⇓–5,15 Recently the UCSF neurosurgical group reported a 5.3% mortality rate and a 4.6% permanent morbidity rate after managing 631 MCA aneurysms (51.9% ruptured aneurysms) in 543 patients.³ Its combined morbidity and mortality rate was 9.9%, which seems less safe than EVT outcome. However, this UCSF study probably included high-risk aneurysms, as did our study (the size of the aneurysm was ≥10 mm in 13.7% of cases, and 53.5% of aneurysms had wide necks; illustrated in Figs 1 and 2). In our series, the percentage of complications was slightly but not significantly higher in the ruptured aneurysms group (17.1%) versus the unruptured aneurysms group (12.2%), as previously reported in a systematic review of MCA aneurysms.⁶ The UCSF group also reported more complications in the case of ruptured aneurysms (8.5% versus 4.9%).

At 1 month, our global mortality and permanent morbidity rates were not negligible (7.3% and 6.3% for unruptured and ruptured aneurysms, respectively). Comparing our series of patients harboring ruptured and unruptured aneurysms who were treated by EVT with a series of patients treated by clipping, short-term mortality and morbidity are not higher. In a series by a UCSF group, at mean follow-up of 30 months, overall mortality and permanent morbidity (mRS ≤2) were 7.6% and 29.3% for unruptured and ruptured aneurysms, respectively.⁶ Twenty-two percent were poor-grade patients (HH grades IV and V) in the UCSF study, whereas 27% were poor-grade in our study.

Several endovascular techniques are currently used, including double catheter,¹¹ balloon-assisted coiling,^12,13 and stent-assisted coiling techniques.^14,17 We used the balloon-assisted coiling technique in many cases (60.3%) without any significant increased complication rate compared with simple coiling, as reported.¹⁸ Interestingly, our study shows that stent placement highly increases a risk of complication compared with other EVT techniques. Moreover, in logistic regression, the odds of developing complications were 4.8 times greater when stents were used. The use of antiplatelet therapy is known to increase the risk of hemorrhagic complications.^14,19 In a survey of the literature that included 1517 patients treated with stents, Shapiro et al¹⁹ found a procedural complication in 19% of patients, which is lower compared with our series (36.8%). Our high complication rate could be related to MCA location, which is more likely to associate with procedural complications in stent-assisted coiling, as recently outlined by Chalouhi et al²⁰ after stent-assisted coiling of 508 intracranial aneurysms. We did not find any significant difference between ruptured and unruptured aneurysms. Improvement in stent technology is warranted to diminish complications and improve the safety of endovascular technology.

In the setting of SAH, the aim of treatment is not an optimal sac occlusion, but its rapid protection. If needed, a complementary treatment will be applied later. In our study, approximately 30% of ruptured aneurysms were related to huge hematomas, 8 needed surgery, and the other patients had favorable outcome. This result suggests that MCA ruptured aneurysms with hematomas can be safely managed without clipping. At this time, antiplatelet therapy is undesirable because of the potential need for a ventriculostomy or craniostomy. For these reasons, stent placement is generally avoided in acutely ruptured aneurysms because its safety is less favorable in ruptured aneurysms. In a systematic review that included 339 patients, Bodily et al²¹ found clinically significant intracranial hemorrhagic and thromboembolic complications in 8% and 6%, respectively.

Complete aneurysm occlusion was achieved in most cases (83.2%); this suggests that EVT could be an effective treatment for all MCA aneurysms. It also showed that EVT is a durable treatment with a low rate of angiographic recurrence at medium-term follow-up. This recurrence rate (15.6%) showed similar results to those of studies of MCA aneurysms in selected patients (13.0–38.3%).⁶ This finding could be explained by the frequent use of balloon-assisted coiling, which appears to increase the long-term anatomic results compared standard coiling.¹⁸ Our study has identified aneurysm size as the only significant risk factor for recurrence, as previously shown.^14,16 Though the rate of aneurysm recurrence appears to be low after surgical clipping, it is difficult to compare a recurrence risk of EVT with surgical clipping because only a few surgical series report long-term follow-up. There was an increased risk of recurrent bleeding from a coiled aneurysm compared with a clipped aneurysm, but the risks were very low.^22,23 In long-term follow-up of the International Subarachnoid Aneurysm Trial patients, 10 rebleedings occurred in the coiled group and 3 in the clipping group.²³ In our series, one ruptured aneurysm bled again within the first 24 hours after treatment (2.4%) on 16.3 (mean) months of follow-up. Results from the Cerebral Aneurysm Rerupture After Treatment were similar with a 1.8% risk of re-rupture in the first year.²⁴

Despite widespread opinion, endovascular therapy should be the treatment of choice for MCA aneurysms, supporting the conclusion reached in the position statement of the American Association of Neurologic Surgeons and American Society of Neuroradiology.²⁵

Limitations

Our study is limited by its small sample size and the absence of randomization between study groups. The results reflect a systematic and routine endovascular approach in an experienced neurovascular center. Because the duration of follow-up was short, the incidence of recurrence probably has been underestimated. However, in most intracranial aneurysms adequately occluded 6 months after coiling, prolonged imaging follow-up within the first 5–10 years after coiling does not seem beneficial in terms of detecting reopened aneurysms that need retreatment.²⁶

Conclusions

Even though stent-assisted coiling significantly increases the risk of procedural complications, endovascular treatment of all MCA aneurysms is safe, effective, and provides durable aneurysm closure.

References

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Received July 17, 2013.
Accepted after revision August 30, 2013.

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American Journal of Neuroradiology

Endovascular Treatment of Middle Cerebral Artery Aneurysms for 120 Nonselected Patients: A Prospective Cohort Study

Abstract

ABBREVIATIONS:

Materials and Methods

Patients

Endovascular Procedures

Data Collection

Data Analysis

Statistical Analysis

Results

Patients

Aneurysms

Technique of Aneurysm Treatment

Complications

Clinical Status

Initial Anatomic Results

(Re)Bleeding/Retreatment

Anatomic Results at Follow-Up

Discussion

Limitations

Conclusions

References

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Opportunities

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