1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [a3e3536e-86f3-435f-ab76-2e835fb03cde] => Array
        (
            [runtime-id] => a3e3536e-86f3-435f-ab76-2e835fb03cde
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [80b66c89-09e5-4905-b108-bf1eafe346c2] => Array
                        (
                            [runtime-id] => 80b66c89-09e5-4905-b108-bf1eafe346c2
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c] => Array
        (
            [runtime-id] => 0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [a4c45b43-cd20-428e-ba1a-de231f42914f] => Array
                        (
                            [runtime-id] => a4c45b43-cd20-428e-ba1a-de231f42914f
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c] => Array
        (
            [runtime-id] => 0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [a4c45b43-cd20-428e-ba1a-de231f42914f] => Array
                        (
                            [runtime-id] => a4c45b43-cd20-428e-ba1a-de231f42914f
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c] => Array
        (
            [runtime-id] => 0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [a4c45b43-cd20-428e-ba1a-de231f42914f] => Array
                        (
                            [runtime-id] => a4c45b43-cd20-428e-ba1a-de231f42914f
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c] => Array
        (
            [runtime-id] => 0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [a4c45b43-cd20-428e-ba1a-de231f42914f] => Array
                        (
                            [runtime-id] => a4c45b43-cd20-428e-ba1a-de231f42914f
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c] => Array
        (
            [runtime-id] => 0e2680bd-5a1e-4a48-80c0-c00dea5bdb3c
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [a4c45b43-cd20-428e-ba1a-de231f42914f] => Array
                        (
                            [runtime-id] => a4c45b43-cd20-428e-ba1a-de231f42914f
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)
1naresh2naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [708e933f-2641-4111-a708-9c30c78793f8] => Array
        (
            [runtime-id] => 708e933f-2641-4111-a708-9c30c78793f8
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [cc533d6a-25f8-4b35-939e-f5f03ad0d1c8] => Array
                        (
                            [runtime-id] => cc533d6a-25f8-4b35-939e-f5f03ad0d1c8
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;dac9ebf4555ffb9e6d26ba9318202797d01bf7cd
                )

        )

)


  
    











    Reply: | American Journal of Neuroradiology  
    


















    


























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

  

    

  
      
  
  

    

  
  
      
ReplyLETTER

  
      

  
      
Reply:
  
    	
M.H.T. Zwartbol, A.G. van der Kolk and M.I. Geerlings

  
    	
American Journal of Neuroradiology May 2020,  41 (5) E32; DOI: https://doi.org/10.3174/ajnr.A6516 

  
  
  



  


  
  



  
      
  
  

    
We thank Dr Alexander and colleagues for their interest in our work and appreciate the opportunity to respond to their concerns.1
A concern is raised regarding the interpretation of our results, which led us to conclude that our findings do not support “a different etiology” between extracranial atherosclerosis (ECAS) and intracranial atherosclerosis (ICAS). We agree with the data used to substantiate their concern, including data on histopathology and etiology, but do not share their opinion that our findings are contradictory. As described in our article—and noted by Alexander et al—there are several limitations to our study design, which is why we tried to carefully word our conclusion to avoid overinterpretation of our results. We showed that there is a relationship between ICAS and several clinical markers of ECAS, suggesting a similar etiology; or in other words (used in the article), our (limited) results do not support a different etiology. However, there are indeed differences in etiology and pathophysiology, which we do not claim to contradict. Apparently, we were not able to successfully convey this subtle difference to all readers.
As carefully described by Alexander et al, ICAS is a complex disease with many facets, and intracranial vessel wall MR imaging (vwMRI) facilitates our attempts to elucidate parts of this disease process. We agree that vwMRI can provide us with information not only on the presence or absence of atherosclerotic plaques but also on plaque components and the (from extracranial atherosclerosis) well-known “vulnerable plaque.” However, most vessel wall lesions encountered in our populations, Caucasian subjects, which Alexander et al justly noted were not specifically mentioned in our article, are too small to accurately measure, let alone characterize, apart from the presence or absence of enhancement.2 It would indeed also have been of interest to correlate vessel wall lesion locations with cerebrovascular symptoms, but this would necessitate a different study population—with more (cerebrovascular) symptomatic patients—to reach any statistically significant results.
Finally, we would like to provide our whole-hearted support for the suggestion of Alexander et al to “refocus the need for tissue validation of vwMRI.” The ease of characterizing extracranial carotid atherosclerotic plaques is in stark contrast with the difficulty of performing the same analyses in intracranial plaques, which is mainly caused by the lack of methods to compare in vivo–acquired vwMRI with ex vivo histopathology. Nonetheless, sequence validation is essential for our conception of how we should interpret vessel wall lesions on vwMRI and how we should incorporate intracranial vwMRI in clinical practice. We would like to thank Alexander and colleagues for their critical review and compliment them on highlighting the possibilities of vwMRI and opportunities for further research.
References
  1. 1.
    1. Zwartbol  MHT, 
    2. Geerlings  MI, 
    3. Ghaznawi  R, et al
    . Intracranial atherosclerotic burden on 7T MRI is associated with markers of extracranial atherosclerosis: the SMART-MR study. AJNR Am J Neuroradiol 2019;40:2016–22 doi:10.3174/ajnr.A630]8 pmid:31806592
  2. 2.
    1. van Hespen  KM, 
    2. Zwanenburg  JJM, 
    3. Harteveld  AA, et al
    . Intracranial vessel wall magnetic resonance imaging does not allow for accurate and precise wall thickness measurements. Stroke 2019;50:e283–84 doi:10.1161/STROKEAHA.119.026497 pmid:31446885
  


  
  



  



    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement