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RT Journal Article
SR Electronic
T1 Functional CT Perfusion Imaging in Predicting the Extent of Cerebral Infarction from a 3-Hour Middle Cerebral Arterial Occlusion in a Primate Stroke Model
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1013
OP 1021
VO 23
IS 6
A1 Hamberg, Leena M.
A1 Hunter, George J.
A1 Maynard, Kenneth I.
A1 Owen, Chris
A1 Morris, Pearse P.
A1 Putman, Christopher M.
A1 Ogilvy, Christopher
A1 González, R. Gilberto
YR 2002
UL http://www.ajnr.org/content/23/6/1013.abstract
AB BACKGROUND AND PURPOSE: Our purpose was to determine whether cerebral perfusion functional CT (fCT), performed after endovascular middle cerebral artery (MCA) occlusion, can be used to predict final cerebral infarction extent in a primate model.METHODS: fCT with bolus tracking was performed before and 30 and 150 minutes after 3-hour digital subtraction angiography (DSA)–guided endovascular MCA occlusion in five baboons. Parametric cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) maps were constructed by voxel-by-voxel gamma variate fitting and used to determine lesion sizes. Animals were sacrificed 48 hours after the occlusion, and ex vivo MR imaging was performed. Lesion sizes on fCT and MR images were compared.RESULTS: Hypoperfusion was clearly identified on all images obtained after MCA occlusion. Thirty and 150 minutes after occlusion onset, respectively, mean lesion sizes were 737 mm2 ± 33 and 737 mm2 ± 44 for CBF, 722 mm2 ± 32 and 730 mm2 ± 43 for CBV, and 819 mm2 ± 14 and 847 mm2 ± 11 for MTT. Mean outcome infarct size on MR images was 733 mm2 ± 30. Measurements based on CBV and CBF (R2 = 0.97 and 0.96, P &lt; .001), but not MTT (R2 = 0.40, P &gt; .5), were highly correlated with final lesion size.CONCLUSION: An endovascular approach to MCA occlusion provides a minimally invasive, reproducible animal model for controlled studies of cerebral ischemia and infarction. Derived cerebral perfusion maps closely predict the 48-hour infarct size after 3-hour MCA occlusion.