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RT Journal Article
SR Electronic
T1 Effects of Physiologic Human Brain Motion on Proton Spectroscopy: Quantitative Analysis and Correction with Cardiac Gating
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 225
OP 230
VO 23
IS 2
A1 Pattany, Pradip M.
A1 Khamis, Imad H.
A1 Bowen, Brian C.
A1 Goodkin, Karl
A1 Weaver, R. Gregory
A1 Murdoch, James B.
A1 Donovan Post, M. Judith
A1 Quencer, Robert M.
YR 2002
UL http://www.ajnr.org/content/23/2/225.abstract
AB Summary: Proton MR spectroscopy is a powerful noninvasive method that enables measurement of certain brain metabolites in healthy subjects and patients with diseases. A major difficulty with clinical and research applications of in vivo proton MR spectroscopy is the variability of metabolite concentrations, especially in regions with substantial physiologic motion. In our preliminary evaluation, we tested the hypothesis that physiologic brain motion leads to lower mean metabolite concentrations and higher SDs for the measured metabolite concentrations.