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PT  - JOURNAL ARTICLE
AU  - Arbab, Ali Syed
AU  - Aoki, Shigeki
AU  - Toyama, Keiji
AU  - Miyazawa, Nobuhiko
AU  - Kumagai, Hiroshi
AU  - Umeda, Takako
AU  - Arai, Takao
AU  - Araki, Tsutomu
AU  - Kabasawa, Hiroyuki
AU  - Takahashi, Yoshiyuki
TI  - Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT
DP  - 2002 Mar 01
TA  - American Journal of Neuroradiology
PG  - 381--388
VI  - 23
IP  - 3
4099  - http://www.ajnr.org/content/23/3/381.short
4100  - http://www.ajnr.org/content/23/3/381.full
SO  - Am. J. Neuroradiol.2002 Mar 01; 23
AB  - BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT).METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images.RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre- and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR resultswere significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82–85%) and accuracy (80–82%) were higher with all pre- and post-acetazolamide images (all TIs).CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion.