1naresh2naresh<pre>Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [b9414d4d-57b9-48a1-b543-85c6a0afaa8b] => Array
        (
            [runtime-id] => b9414d4d-57b9-48a1-b543-85c6a0afaa8b
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [8b2c0487-fe9a-4049-aa5d-d799c5af5249] => Array
                        (
                            [runtime-id] => 8b2c0487-fe9a-4049-aa5d-d799c5af5249
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;491aa50527ddfb059abf86bbfe61f21963bcdcb6
                )

        )

)
1naresh2naresh<pre>Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

    [63f08d81-fe3a-488b-b8cb-754f09371cf0] => Array
        (
            [runtime-id] => 63f08d81-fe3a-488b-b8cb-754f09371cf0
            [type] => toll-free-key
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [ddcaee51-66e5-495a-8255-f55e6ab712e8] => Array
                        (
                            [runtime-id] => ddcaee51-66e5-495a-8255-f55e6ab712e8
                            [type] => toll-free-key
                        )

                )

            [credentials] => Array
                (
                    [method] => toll-free-key
                    [value] => tf_ipsecsha;491aa50527ddfb059abf86bbfe61f21963bcdcb6
                )

        )

)
RT Journal Article
SR Electronic
T1 Identification of a By-Product of Nitric Oxide Synthase Activity in Human Acute Brain Injury with in Vivo Proton Magnetic Resonance Spectroscopy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 389
OP 392
VO 23
IS 3
A1 Silberstein, Morry
A1 Lane, Dianne
A1 Dodd, Seetal
A1 Opeskin, Kenneth
YR 2002
UL http://www.ajnr.org/content/23/3/389.abstract
AB BACKGROUND AND PURPOSE: Laboratory studies have been used to identify nitric oxide as a notable mediator in neuronal death after acute brain injury. To our knowledge, this has not previously been confirmed with in vivo study in humans. Our purpose was to seek in vivo evidence for the induction of nitric oxide synthase (NOS) in human acute brain injury by using proton MR spectroscopy.METHODS: In vitro proton MR spectra were obtained in neural extracts from 30 human cadavers, and in vivo spectra were obtained in 20 patients with acute brain injury and in a similar number of control subjects.RESULTS: We identified a unique peak at 3.15 ppm by using in vivo proton MR spectroscopy in eight of 20 patients with acute brain injury but not in 20 healthy volunteers (P &lt; .002). On the basis of in vitro data, we have tentatively assigned this peak to citrulline, a NOS by-product.CONCLUSION: To our knowledge, our findings suggest, for the first time, that excitotoxicity may occur in human acute brain injury. Confirmation with the acquisition of spectra in very early acute cerebral injury would provide a rationale for the use of neuroprotective agents in these conditions, as well as a new noninvasive method for quantification.