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PT  - JOURNAL ARTICLE
AU  - Wu, Wen-Chau
AU  - Chen, Cheng-Yu
AU  - Chung, Hsiao-Wen
AU  - Juan, Chun-Jung
AU  - Hsueh, Chun-Jen
AU  - Gao, Hong-Wei
TI  - Discrepant MR Spectroscopic and Perfusion Imaging Results in a Case of Malignant Transformation of Cerebral Glioma
DP  - 2002 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1775--1778
VI  - 23
IP  - 10
4099  - http://www.ajnr.org/content/23/10/1775.short
4100  - http://www.ajnr.org/content/23/10/1775.full
SO  - Am. J. Neuroradiol.2002 Nov 01; 23
AB  - Summary: We present serial MR perfusion and spectroscopic findings of a pathologically proved low grade glioma, which evolved into glioblastoma multiforme in 2 years in a 24-year-old man. The initial MR imaging studies, including enhanced conventional T1-weighted and perfusion imaging, were characteristic of a benign glioma with the only exception being that multi-voxel proton MR spectroscopy showed malignant features with a high choline:phosphocreatine ratio. Postoperative follow-up MR imaging revealed findings consistent with malignant glioma, with increased angiogenesis on perfusion images and heterogeneous enhancement on contrast-enhanced T1-weighted images that were further confirmed by second surgery. We suggest conducting close MR imaging follow-up of patients with glioma who have discrepant MR spectroscopic and perfusion results after treatment.