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RT Journal Article
SR Electronic
T1 Rapid Development of Optic Glioma in a Patient with Hybrid Phakomatosis: Neurofibromatosis Type 1 and Tuberous Sclerosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 36
OP 38
VO 25
IS 1
A1 Erbay, Sami H.
A1 Oljeski, Stephen A.
A1 Bhadelia, Rafeeque
YR 2004
UL http://www.ajnr.org/content/25/1/36.abstract
AB Summary: Increased propensity for tumor formation in neurofibromatosis and tuberous sclerosis exists because of defective tumor-suppressor genes. Although different tumor-suppressor genes may be involved in neurofibromatosis and tuberous sclerosis, at the cellular level these genes share rather common enzymatic pathways. We believe these genetic malfunctions have resulted in a cumulative or additive effect for rapid growth of optic glioma in the following unusual case that has hybrid phakomatosis.