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PT  - JOURNAL ARTICLE
AU  - Ionita, Catalina
AU  - Wasay, Mohammed
AU  - Balos, Lucia
AU  - Bakshi, Rohit
TI  - MR Imaging in Toxoplasmosis Encephalitis after Bone Marrow Transplantation: Paucity of Enhancement despite Fulminant Disease
DP  - 2004 Feb 01
TA  - American Journal of Neuroradiology
PG  - 270--273
VI  - 25
IP  - 2
4099  - http://www.ajnr.org/content/25/2/270.short
4100  - http://www.ajnr.org/content/25/2/270.full
SO  - Am. J. Neuroradiol.2004 Feb 01; 25
AB  - Summary: We present a patient who underwent bone marrow transplantation (BMT) after developing chronic myelocytic leukemia. Four months after BMT, he became comatose and died. MR imaging revealed multifocal brain lesions that were progressive but produced no edema. Postcontrast studies revealed that most of the lesions were nonenhancing. There was only discrete, irregular leptomeningeal enhancement with possible minimal enhancement of the cortex and subcortical white matter. Autopsy showed overwhelming toxoplasmosis encephalitis. This case illustrates that toxoplasmosis lesions may lack obvious contrast enhancement in the brain of the immunocompromised patients, despite severe involvement. Recognition of this unusual MR imaging manifestation of toxoplasmosis should lead to earlier diagnosis and treatment.