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RT Journal Article
SR Electronic
T1 Disappearing Calvarium in Gorham Disease: MR Imaging Characteristics with Pathologic Correlation
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 415
OP 418
VO 25
IS 3
A1 Lo, Chung-Ping
A1 Chen, Cheng-Yu
A1 Chin, Shy-Chyi
A1 Juan, Chun-Jung
A1 Hsueh, Chun-Jen
A1 Chen, Ann
YR 2004
UL http://www.ajnr.org/content/25/3/415.abstract
AB Summary: Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced T1-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion.