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RT Journal Article
SR Electronic
T1 Diagnostic Value of Multiparameter MRI-Based Radiomics in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorders
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1425
OP 1431
DO 10.3174/ajnr.A8045
VO 44
IS 12
A1 Li, Ting
A1 Chen, Xin
A1 Jing, Yang
A1 Wang, Haoru
A1 Zhang, Ting
A1 Zhang, Li
A1 Ding, Hao
A1 Xie, Mingye
A1 He, Ling
YR 2023
UL http://www.ajnr.org/content/44/12/1425.abstract
AB BACKGROUND AND PURPOSE: Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) have a higher prevalence among children. For children undergoing the initial manifestation of MOGAD, prompt diagnosis has paramount importance. This study assessed the performance of multiparameter MRI-based radiomics in distinguishing patients with and without MOGAD with idiopathic inflammatory demyelinating diseases.MATERIALS AND METHODS: We enrolled a cohort of 121 patients diagnosed with idiopathic inflammatory demyelinating diseases, including 68 children with MOGAD and 53 children without MOGAD. Radiomics models (T1WI, T2WI, FLAIR, and compound model) using features extracted from demyelinating lesions within the brain parenchyma were developed in the training set. The performance of these models underwent validation within the internal testing set. Additionally, we gathered clinical factors and MRI features of brain parenchymal lesions at their initial presentation. Subsequently, these variables were used in the construction of a clinical prediction model through multivariate logistic regression analysis.RESULTS: The areas under the curve for the radiomics models (T1WI, T2WI, FLAIR, and the compound model) in the training set were 0.781 (95% CI, 0.689–0.864), 0.959 (95% CI, 0.924–0.987), 0.939 (95% CI, 0.898–0.979), and 0.989 (95% CI, 0.976–0.999), respectively. The areas under the curve for the radiomics models (T1WI, T2WI, FLAIR, and the compound model) in the testing set were 0.500 (95% CI, 0.304–0.652), 0.833 (95% CI, 0.697–0.944), 0.804 (95% CI, 0.664–0.918), and 0.905 (95% CI, 0.803–0.979), respectively. The areas under the curve of the clinical prediction model in the training set and testing set were 0.700 and 0.289, respectively.CONCLUSIONS: Multiparameter MRI-based radiomics helps distinguish MOGAD from non-MOGAD in patients with idiopathic inflammatory demyelinating diseases.AUCarea under the ROC curveIIDDsidiopathic inflammatory demyelinating diseasesLASSOleast absolute shrinkage and selection operatorMOGmyelin oligodendrocyte glycoproteinMOGADmyelin oligodendrocyte glycoprotein antibody associated disordersNMOSDneuromyelitis optica spectrum disorderROCreceiver operating characteristic