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RT Journal Article
SR Electronic
T1 Primary Diffuse Meningeal Melanomatosis: Radiologic-Pathologic Correlation
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 115
OP 118
VO 24
IS 1
A1 Pirini, Maria-Giulia
A1 Mascalchi, Mario
A1 Salvi, Fabrizio
A1 Tassinari, Carlo A.
A1 Zanella, Licciana
A1 Bacchini, Patrizia
A1 Bertoni, Franco
A1 D’Errico, Antonia
A1 Corti, Barbara
A1 Grigioni, Walter F.
YR 2003
UL http://www.ajnr.org/content/24/1/115.abstract
AB Summary: We report a case of primary diffuse meningeal melanomatosis, a rare variant of primary malignant melanoma of the CNS, in a 68-year-old woman. The disease mimicked intracranial hypotension syndrome and was diagnosed only at autopsy (CSF cytologic results were negative). CT revealed hydrocephalus with effacement of the cerebral convexity sulci and abnormal contrast enhancement in the right sylvian and frontoparietal fissures, whereas MR imaging showed diffuse marked dural and leptomeningeal contrast enhancement. In retrospect, these nonspecific findings correlated with the extensive leptomeningeal invasion in the cerebral hemispheres, brain stem and spinal cord. The clinical, radiologic, and pathologic features of diffuse meningeal melanomatosis are reviewed.