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RT Journal Article
SR Electronic
T1 Reduced Cortical Thickness Correlates of Cognitive Dysfunction in Post-COVID-19 Condition: Insights from a Long-Term Follow-up
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 647
OP 654
DO 10.3174/ajnr.A8167
VO 45
IS 5
A1 Dacosta-Aguayo, Rosalia
A1 Puig, Josep
A1 Lamonja-Vicente, Noemi
A1 Carmona-Cervelló, Meritxell
A1 León-Gómez, Brenda Biaani
A1 Monté-Rubio, Gemma
A1 López-Linfante, Victor M.
A1 Zamora-Putin, Valeria
A1 Montero-Alia, Pilar
A1 Chacon, Carla
A1 Bielsa, Jofre
A1 Moreno-Gabriel, Eduard
A1 Garcia-Sierra, Rosa
A1 Pachón, Alba
A1 Costa, Anna
A1 Mataró, Maria
A1 Prado, Julia G.
A1 Martinez-Cáceres, Eva
A1 Mateu, Lourdes
A1 Massanella, Marta
A1 Violán, Concepción
A1 Torán-Monserrat, Pere
A1 for the Aliança ProHEpiC-19 Cognitiu (The APC Collaborative Group)
YR 2024
UL http://www.ajnr.org/content/45/5/647.abstract
AB BACKGROUND AND PURPOSE: There is a paucity of data on long-term neuroimaging findings from individuals who have developed the post-coronavirus 2019 (COVID-19) condition. Only 2 studies have investigated the correlations between cognitive assessment results and structural MR imaging in this population. This study aimed to elucidate the long-term cognitive outcomes of participants with the post-COVID-19 condition and to correlate these cognitive findings with structural MR imaging data in the post-COVID-19 condition.MATERIALS AND METHODS: A cohort of 53 participants with the post-COVID-19 condition underwent 3T brain MR imaging with T1 and FLAIR sequences obtained a median of 1.8 years after Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection. A comprehensive neuropsychological battery was used to assess several cognitive domains in the same individuals. Correlations between cognitive domains and whole-brain voxel-based morphometry were performed. Different ROIs from FreeSurfer were used to perform the same correlations with other neuroimaging features.RESULTS: According to the Frascati criteria, more than one-half of the participants had deficits in the attentional (55%, n = 29) and executive (59%, n = 31) domains, while 40% (n = 21) had impairment in the memory domain. Only 1 participant (1.89%) showed problems in the visuospatial and visuoconstructive domains. We observed that reduced cortical thickness in the left parahippocampal region (t(48) = 2.28, P = .03) and the right caudal-middle-frontal region (t(48) = 2.20, P = .03) was positively correlated with the memory domain.CONCLUSIONS: Our findings suggest that cognitive impairment in individuals with the post-COVID-19 condition is associated with long-term alterations in the structure of the brain. These macrostructural changes may provide insight into the nature of cognitive symptoms.BMIbody mass indexCOVID-19coronavirus disease 2019PCCpost-COVID-19 conditionreproaReproducibility AnalysisSARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2WAISWechsler Adult Intelligence ScaleWHOWorld Health Organization