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PT  - JOURNAL ARTICLE
AU  - Lee, Kevin
AU  - Mahmud, Meem
AU  - Marx, Darby
AU  - Yasen, Weiye
AU  - Sharma, Omna
AU  - Ivanidze, Jana
AU  - Zan, Elcin
AU  - Zhou, Liangdong
AU  - Li, Yi
AU  - de Leon, Mony J.
AU  - Nordvig, Anna S.
AU  - Chiang, Gloria C.
TI  - Clinical Arterial Spin-Labeling MR Imaging to Screen for Typical and Atypical Neurodegenerative Disease in the New Era of Alzheimer Treatment
AID  - 10.3174/ajnr.A8164
DP  - 2024 May 01
TA  - American Journal of Neuroradiology
PG  - 632--636
VI  - 45
IP  - 5
4099  - http://www.ajnr.org/content/45/5/632.short
4100  - http://www.ajnr.org/content/45/5/632.full
SO  - Am. J. Neuroradiol.2024 May 01; 45
AB  - SUMMARY: The clinical standard of care in the diagnosis of neurodegenerative diseases relies on [18F] FDG-PET/CT or PET MR imaging. Limitations of FDG-PET include cost, the need for IV access, radiation exposure, and availability. Arterial spin-labeling MR imaging has been shown in research settings to be useful as a proxy for FDG-PET in differentiating Alzheimer disease from frontotemporal dementia. However, it is not yet widely used in clinical practice, except in cerebrovascular disease. Here, we present 7 patients, imaged with our routine clinical protocol with diverse presentations of Alzheimer disease and other neurodegenerative diseases, in whom arterial spin-labeling–derived reduced CBF correlated with hypometabolism or amyloid/tau deposition on PET. Our case series illustrates the clinical diagnostic utility of arterial spin-labeling MR imaging as a fast, accessible, and noncontrast screening tool for neurodegenerative disease. Arterial spin-labeling MR imaging can guide patient selection for subsequent PET or fluid biomarker work-up, as well as for possible therapy with antiamyloid monoclonal antibodies.ADAlzheimer diseaseADLsactivities of daily livingASLarterial spin-labelingCIcognitive impairmentCOVID-19coronavirus 2019lvPPAlogopenic variant progressive aphasiaMCImild cognitive impairmentMoCAMontreal Cognitive AssessmentPCAposterior cortical atrophy