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RT Journal Article
SR Electronic
T1 Reversible White Matter Lesion in Methionine Adenosyltransferase I/III Deficiency
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1843
OP 1845
VO 25
IS 10
A1 Tada, Hiroko
A1 Takanashi, Jun-ichi
A1 Barkovich, A. James
A1 Yamamoto, Shigenori
A1 Kohno, Yoichi
YR 2004
UL http://www.ajnr.org/content/25/10/1843.abstract
AB Summary: A 5-year-old boy with methionine adenosyltransferase (MAT) I/III deficiency, under treatment for the tentative diagnosis of homocystinuria, presented with mildly decreased appetite and sleepiness. MR imaging showed abnormal T1 and T2 prolongations and reduced diffusion in the cerebral white matter. Clinical symptoms and MR imaging findings improved after discontinuation of therapy. We speculate that inappropriate treatment might enhance CNS lesions of MAT I/III deficiency by causing a reversible vacuolating myelinopathy.