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PT  - JOURNAL ARTICLE
AU  - Valente, Marcelo
AU  - Valente, Kette D.
AU  - Sugayama, Sofia S. M.
AU  - Kim, Chong Ae
TI  - Malformation of Cortical and Vascular Development in One Family with Parietal Foramina Determined by an <em>ALX4</em> Homeobox Gene Mutation
DP  - 2004 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1836--1839
VI  - 25
IP  - 10
4099  - http://www.ajnr.org/content/25/10/1836.short
4100  - http://www.ajnr.org/content/25/10/1836.full
SO  - Am. J. Neuroradiol.2004 Nov 01; 25
AB  - Summary: Vascular and cortical anomalies have been found in a family with parietal foramina type 2 (PFM2), which is determined by the ALX4 gene. It is believed that ALX4 has a bone-restricted expression. We report a case of PFM with age-related size variation in a 4-year-old boy, as well as in his mother, aunt and grandfather. MR imaging of the child demonstrates prominent malformations of cortical (polymicrogyric cortex with an unusual infolding pattern) and vascular development (persistence median prosencephalic vein), associated with high tentorial incisure periatrial white matter changes.