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PT  - JOURNAL ARTICLE
AU  - Sandoval, Claudio
AU  - Kutscher, Martin
AU  - Jayabose, Somasundaram
AU  - Tenner, Michael
TI  - Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings
DP  - 2003 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1887--1890
VI  - 24
IP  - 9
4099  - http://www.ajnr.org/content/24/9/1887.short
4100  - http://www.ajnr.org/content/24/9/1887.full
SO  - Am. J. Neuroradiol.2003 Oct 01; 24
AB  - Summary: We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion. We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.