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PT  - JOURNAL ARTICLE
AU  - Martin, David D.
AU  - Seeger, Uwe
AU  - Ranke, Michael B.
AU  - Grodd, Wolfgang
TI  - MR Imaging and Spectroscopy of a Tuber Cinereum Hamartoma in a Patient with Growth Hormone Deficiency and Hypogonadotropic Hypogonadism
DP  - 2003 Jun 01
TA  - American Journal of Neuroradiology
PG  - 1177--1180
VI  - 24
IP  - 6
4099  - http://www.ajnr.org/content/24/6/1177.short
4100  - http://www.ajnr.org/content/24/6/1177.full
SO  - Am. J. Neuroradiol.2003 Jun 01; 24
AB  - Summary: To our knowledge, this is the first report of hypogonadotropic hypogonadism, or growth hormone deficiency, in a patient without non-Pallister-Hall syndrome who had hypothalamic hamartoma diagnosed on the basis of MR imaging and MR spectroscopy findings. On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in the amygdala. However, myo-inositol concentration was elevated in the hamartoma compared with that in the amygdala and thalamus. This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used.