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PT  - JOURNAL ARTICLE
AU  - Zand, Dina J.
AU  - Simon, Erin M.
AU  - Pulitzer, Steven B.
AU  - Wang, D.J.
AU  - Wang, Z.J.
AU  - Rorke, Lucy B.
AU  - Palmieri, Michael
AU  - Berry, Gerard T.
TI  - In Vivo Pyruvate Detected by MR Spectroscopy in Neonatal Pyruvate Dehydrogenase Deficiency
DP  - 2003 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1471--1474
VI  - 24
IP  - 7
4099  - http://www.ajnr.org/content/24/7/1471.short
4100  - http://www.ajnr.org/content/24/7/1471.full
SO  - Am. J. Neuroradiol.2003 Aug 01; 24
AB  - Summary: We present a unique finding of an elevated level of pyruvate at 2.37 ppm revealed by in vivo MR spectroscopy of a female neonate. Low fibroblast pyruvate dehydrogenase (PDH) complex activity subsequently confirmed a diagnosis of PDH deficiency. Abnormalities of brain development consistent with PDH deficiency were also evident on fetal and postnatal MR images. To our knowledge, this is the first report of pyruvate being shown in vivo in a child and the first report of MR spectroscopy aiding in the diagnosis of inborn error in pyruvate metabolism before confirmation by conventional enzymatic testing. This finding has potential implications for earlier diagnosis in patients with defects in mitochondrial metabolism.