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PT  - JOURNAL ARTICLE
AU  - Cau, Riccardo
AU  - Anzalone, Nicoletta
AU  - Mannelli, Lorenzo
AU  - Edjlali, Myriam
AU  - Balestrieri, Antonella
AU  - Nardi, Valentina
AU  - Lanzino, Giuseppe
AU  - Lerman, Amir
AU  - Suri, Jasjit S.
AU  - Saba, Luca
TI  - Pericarotid Fat as a Marker of Cerebrovascular Risk
AID  - 10.3174/ajnr.A8300
DP  - 2024 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1635--1641
VI  - 45
IP  - 11
4099  - http://www.ajnr.org/content/45/11/1635.short
4100  - http://www.ajnr.org/content/45/11/1635.full
SO  - Am. J. Neuroradiol.2024 Nov 01; 45
AB  - Vascular inflammation is widely recognized as an important factor in the atherosclerotic process, particularly in terms of plaque development and progression. Conventional tests, such as measuring circulating inflammatory biomarkers, lack the precision to identify specific areas of vascular inflammation. In this context, noninvasive imaging modalities can detect perivascular fat changes, serving as a marker of vascular inflammation. This review aims to provide a comprehensive overview of the key concepts related to perivascular carotid fat and its pathophysiology. Additionally, we examine the existing literature on the association of pericarotid fat with features of plaque vulnerability and cerebrovascular events. Finally, we scrutinize the advantages and limitations of the noninvasive assessment of pericarotid fat.AIartificial intelligenceAUCarea under the curveHUHounsfield unitPCFpericarotid fatPVATperivascular adipose tissueUSultrasoundUSPIOultra-small superparamagnetic iron oxide particles