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PT  - JOURNAL ARTICLE
AU  - Koneru, Manisha
AU  - Mei, Janet Y.
AU  - Lakhani, Dhairya A.
AU  - Salim, Hamza A.
AU  - Shahriari, Mona
AU  - Dmytriw, Adam A.
AU  - Guenego, Adrien
AU  - Heit, Jeremy J.
AU  - Albers, Gregory W.
AU  - Wolman, Dylan
AU  - Faizy, Tobias D.
AU  - Pulli, Benjamin
AU  - Vagal, Vaibhav
AU  - Sriwastwa, Aakanksha
AU  - Aziz, Yasmin
AU  - Xu, Risheng
AU  - Lu, Hanzhang
AU  - Urrutia, Victor C.
AU  - Marsh, Elisabeth B.
AU  - Leigh, Richard
AU  - Bahouth, Mona
AU  - Llinas, Rafael H.
AU  - Nael, Kambiz
AU  - Hillis, ArgyeE.
AU  - Yedavalli, Vivek S.
TI  - Prolonged Venous Transit on Perfusion Imaging is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions
AID  - 10.3174/ajnr.A8611
DP  - 2024 Nov 26
TA  - American Journal of Neuroradiology
PG  - ajnr.A8611
4099  - http://www.ajnr.org/content/early/2024/11/26/ajnr.A8611.short
4100  - http://www.ajnr.org/content/early/2024/11/26/ajnr.A8611.full
AB  - BACKGROUND AND PURPOSE: Prolonged venous transit (PVT+) is a marker of venous outflow; it is defined as the presence or absence of time-to-maximum ≥10 seconds timing in either the superior sagittal sinus or torcula. This novel perfusion imaging-based metric has been associated with higher odds of mortality and lower odds of functional recovery. This study aims to assess the relationship between PVT on admission perfusion imaging and length of hospital stay in large vessel occlusion strokes successfully reperfused with mechanical thrombectomy.MATERIALS AND METHODS: Acute ischemic stroke patients with large vessel occlusions in the anterior circulation successfully treated with thrombectomy between 01/2017 and 09/2022 were retrospectively reviewed. The primary outcome was length of stay in the hospital due to the acute stroke event. Univariable and forward stepwise multivariable linear regressions were performed for the primary outcome.RESULTS: Of 109 patients meeting inclusion, median age was 71 (interquartile range [IQR] 62-80) years. Median hospital length of stay was significantly greater in PVT+ patients (9 [IQR 6-18] days) compared to PVT-patients (6 [IQR 4-12] days, p=0.03). In multivariable regression, PVT+ was significantly associated with length of stay, and PVT+ was associated with approximately two additional days of hospital stay compared to PVT-(p=0.03).CONCLUSIONS: In successfully reperfused large vessel occlusion strokes, PVT+ was associated with an additional two days of hospital stay on average compared to PVT-patients, when adjusting for other clinical covariables. This simple, novel imaging metric is robust in correlating with a range of short and long term clinical outcomes.ABBREVIATIONS: VO = venous outflow; Tmax = time-to-maximum; PVT = prolonged venous transit; AIS-LVO = large vessel occlusion ischemic stroke; SSS = superior sagittal sinus; rCBF = relative cerebral blood flow; IQR = interquartile range; VIF = variance inflation factor.