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RT Journal Article
SR Electronic
T1 Noncontrast MRI Surveillance of Craniopharyngiomas Using a Balanced Steady-state Free Precession (bSSFP) Sequence
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A8439
A1 Trinh, Kelly
A1 Tang, Michael
A1 White-Dzuro, Claire
A1 Lang, Min
A1 Buch, Karen
A1 Rincon, Sandra
YR 2025
UL http://www.ajnr.org/content/early/2024/12/20/ajnr.A8439.abstract
AB BACKGROUND AND PURPOSE: Contrast-enhanced MRI (CEMRI) is a commonly used imaging technique for craniopharyngioma surveillance; however, it carries risks such as allergic reaction and gadolinium deposition. This study evaluates the efficacy of non contrast–enhanced MRI (NCMRI) with a balanced steady-state free precession (bSSFP) sequence compared with CEMRI T1-weighted imaging for craniopharyngioma surveillance.MATERIALS AND METHODS: Twenty-nine patients with craniopharyngioma (16 females/13 males, mean age =21.5 ± 4.3 years) with CEMRIs, including a bSSFP sequence, were evaluated. For each patient, 2 blinded neuroradiologists compared the dimensions of residual craniopharyngioma on non-contrast– and contrast-enhanced sequences. Tumor volume and solid/cystic component measurements were evaluated by using paired t-tests. Diagnostic confidence levels for non-contrast– and contrast-enhanced evaluations were measured by using a 3-point scale (2 = confident, 1 = adequate, 0 = unsure). Analyses of tumor involvement of cranial nerves (CNs) and adjacent vasculature and diagnostic confidence were performed by using Fisher exact and chi-square tests.RESULTS: No significant difference was observed between residual tumor volumes in both studies (18.86 ± 21.67 cm3 versus 17.64 ± 23.85 cm3, P = .55) and measurements of dominant solid component volume, number of cystic components, and largest cystic component volume (2.71 ± 3.47 cm3 versus 3.95 ± 5.51 cm3, P = .10; 2.5 ± 1.5 versus 2.9 ± 1.5, P = .10; 7.61 ± 13.41 versus 6.84 ± 13.37 cm3, P = .22, respectively). Tumor involvement of CNs II (P = .64), III (P = .42), and adjacent vasculature (P = .05) showed no significant differences in detection. Diagnostic confidence was comparable in evaluating CN II, vascular structures, and third ventricle (P &gt; .05) involvement. Higher levels of confidence were observed with bSSFP sequences for the detection of CN III involvement (P = .0001) and with contrast-enhanced T1-weighted imaging for cavernous sinus involvement (P = .02).CONCLUSIONS: NCMRI techniques by using a bSSFP sequence provide similar characterization of craniopharyngiomas as contrast-enhanced techniques.ACAanterior cerebral arterybSSFPbalanced steady-state free precessionCEMRIcontrast-enhanced MRIce-T1Wcontrast-enhanced T1-weighted imagingCNcranial nerveNCMRInon-contrast–enhanced MRITRtotal resection