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PT  - JOURNAL ARTICLE
AU  - Bigler, Erin D.
AU  - Tate, David F.
AU  - Neeley, E. Shannon
AU  - Wolfson, Lara J.
AU  - Miller, Michael J.
AU  - Rice, Sara A.
AU  - Cleavinger, Howard
AU  - Anderson, Carol
AU  - Coon, Hilary
AU  - Ozonoff, Sally
AU  - Johnson, Michael
AU  - Dinh, Elena
AU  - Lu, Jeff
AU  - Mc Mahon, William
AU  - Lainhart, Janet E.
TI  - Temporal Lobe, Autism, and Macrocephaly
DP  - 2003 Nov 01
TA  - American Journal of Neuroradiology
PG  - 2066--2076
VI  - 24
IP  - 10
4099  - http://www.ajnr.org/content/24/10/2066.short
4100  - http://www.ajnr.org/content/24/10/2066.full
SO  - Am. J. Neuroradiol.2003 Nov 01; 24
AB  - BACKGROUND AND PURPOSE: Because of increased prevalence of macrocephaly in autism, head size must be controlled for in studies that examine volumetric findings of the temporal lobe in autistic subjects. We prospectively examined temporal lobe structures in individuals with autism who were normocephalic or macrocephalic (head circumference &amp;gt; 97th percentile) and in control subjects who were normocephalic or macrocephalic or who had a reading disorder (unselected for head size). The rationale for the reading disorder group was to have control subjects with potential temporal lobe anomalies, but who were not autistic.METHODS: In individuals aged 7–31 years, autism was diagnosed on the basis of standardized interview and diagnostic criteria. Control subjects ranged in age from 7 to 22 years. All subjects were male. MR morphometrics of the major temporal lobe structures were based on ANALYZE segmentation routines, in which total brain volume and total intracranial volume (TICV) were calculated. Both group comparisons and developmental analyses were performed.RESULTS: No distinct temporal lobe abnormalities of volume were observed once head size (TICV) was controlled for. In autistic and control subjects, robust growth patterns were observed in white and gray matter that differed little between the groups. Although subtle differences were observed in some structures (ie, less white matter volume in the region of the temporal stem and overall temporal lobe), none was statistically significant.CONCLUSION: No major volumetric anomalies of the temporal lobe were found in cases of autism when IQ, TICV, and age were controlled. Temporal lobe abnormalities that may be associated with autism are likely to be more related to functional organization within the temporal lobe than to any gross volumetric difference.