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RT Journal Article
SR Electronic
T1 Clinical Correlates of White Matter Blood Flow Perfusion Changes in Sturge-Weber Syndrome: A Dynamic MR Perfusion-Weighted Imaging Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1280
OP 1285
DO 10.3174/ajnr.A2540
VO 32
IS 7
A1 Miao, Y.
A1 Juhász, C.
A1 Wu, J.
A1 Tarabishy, B.
A1 Lang, Z.
A1 Behen, M.E.
A1 Kou, Z.
A1 Ye, Y.
A1 Chugani, H.T.
A1 Hu, J.
YR 2011
UL http://www.ajnr.org/content/32/7/1280.abstract
AB BACKGROUND AND PURPOSE: Low brain tissue perfusion due to abnormal venous drainage is thought to be a central mechanism of brain damage in SWS. Here, HR-PWI was used to quantify WM perfusion abnormalities and to correlate these with brain atrophy and clinical variables. MATERIALS AND METHODS: Fourteen children (age range, 0.8–10.0 years) with unilateral SWS underwent MR imaging examinations, including HR-PWI. rCBV, rCBF, and MTT in the affected WM and in contralateral homotopic WM were measured. AI for each perfusion parameter was correlated with age, brain atrophy, and motor and seizure variables as well as IQ. RESULTS: Increased perfusion was seen in the affected hemisphere in 5 children and decreased perfusion in 9 children. Brain atrophy was more severe in the low-perfusion group (P = .01) and was related to both CBF-AI and CBV-AI (r = −0.69, P = .007; r = −0.64, P = .014, respectively). Older children had lower CBV values on the affected side (r = −0.62, P = .02). Longer duration of epilepsy was related to lower CBF (more negative CBF-AI, r = −0.58, P = .03) and low CBV (r = −0.55, P = .04) on the affected side. Lower perfusion was associated with more frequent seizures (rCBF-AI: r = −0.56, P = .04; rCBV-AI: r = −0.63, P = .02). CONCLUSIONS: Increased perfusion in the affected cerebral WM may indicate an early stage of SWS without severe brain atrophy. Decreased perfusion is associated with frequent seizures, long duration of epilepsy, and brain atrophy. AIasymmetry indexAIccalculated asymmetry indexAIshemispheric perfusion parameterAmrage at MR examinationAszage at first seizureBAbrain atrophyCBFcerebral blood flowCBVcerebral blood volumeContcontralateral (to angioma)HR-PWIhigh-resolution perfusion-weighted imagingIpsiipsilateralIQintelligence quotientMTTmean transit timePETpositron-emission tomographyPHTphenytoinPWIperfusion-weighted imagingrCBFrelative cerebral blood flowrCBVrelative cerebral blood volumerHPrelative high perfusionrLPrelative low perfusionrMTTrelative mean transit timeROIregion of interestSPECTsingle-photon emission CTSPINSignal intensity Process in NeuroimagingSWSSturge-Weber syndromeT1WIT1-weighted imagingT2WIT2-weighted imagingWMwhite matter