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RT Journal Article
SR Electronic
T1 MR Imaging of the Hippocampus in Normal Pressure Hydrocephalus: Correlations with Cortical Alzheimer's Disease Confirmed by Pathologic Analysis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 409
OP 414
VO 21
IS 2
A1 Savolainen, Sakari
A1 Laakso, Mikko P.
A1 Paljärvi, Leo
A1 Alafuzoff, Irina
A1 Hurskainen, Heleena
A1 Partanen, Kaarina
A1 Soininen, Hilkka
A1 Vapalahti, Matti
YR 2000
UL http://www.ajnr.org/content/21/2/409.abstract
AB BACKGROUND AND PURPOSE: MR studies have shown hippocampal atrophy to be a sensitive diagnostic feature of Alzheimer's disease (AD). In this study, we measured the hippocampal volumes of patients with a clinical diagnosis of normal pressure hydrocephalus (NPH), a potentially reversible cause of dementia when shunted. Further, we examined the relationship between the hippocampal volumes and cortical AD pathologic findings, intracranial pressure, and clinical outcomes in cases of NPH.METHODS: We measured hippocampal volumes from 37 patients with a clinical diagnosis of NPH (27 control volunteers and 24 patients with AD). The patients with NPH underwent biopsy, and their clinical outcomes were followed for a year.RESULTS: Compared with those for control volunteers, the findings for patients with NPH included a minor left-side decrease in the hippocampal volumes (P &lt; .05). Compared with those for patients with AD, the findings for patients with NPH included significantly larger hippocampi on both sides. Although not statistically significant, trends toward larger volumes were observed in patients with NPH who had elevated intracranial pressure, who benefited from shunting, and who did not display cortical AD pathologic findings.CONCLUSIONS: Measurements of hippocampal volumes among patients with a clinical diagnosis of NPH have clear clinical implications, providing diagnostic discrimination from AD and possibly prediction of clinical outcome after shunting.