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PT  - JOURNAL ARTICLE
AU  - Bargalló, Nuria
AU  - Burrel, Marta
AU  - Berenguer, Joan
AU  - Cofan, Federico
AU  - Buñesch, Laura
AU  - Mercader, Josep M.
TI  - Cortical Laminar Necrosis Caused by Immunosuppressive Therapy and Chemotherapy
DP  - 2000 Mar 01
TA  - American Journal of Neuroradiology
PG  - 479--484
VI  - 21
IP  - 3
4099  - http://www.ajnr.org/content/21/3/479.short
4100  - http://www.ajnr.org/content/21/3/479.full
SO  - Am. J. Neuroradiol.2000 Mar 01; 21
AB  - Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). Initial neuroradiologic studies showed cortical and white matter involvement. Follow-up studies showed cortical hyperintense lesions on T1-weighted MR images, consistent with cortical laminar necrosis. The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients.