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RT Journal Article
SR Electronic
T1 Cortical Laminar Necrosis Caused by Immunosuppressive Therapy and Chemotherapy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 479
OP 484
VO 21
IS 3
A1 Bargalló, Nuria
A1 Burrel, Marta
A1 Berenguer, Joan
A1 Cofan, Federico
A1 Buñesch, Laura
A1 Mercader, Josep M.
YR 2000
UL http://www.ajnr.org/content/21/3/479.abstract
AB Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). Initial neuroradiologic studies showed cortical and white matter involvement. Follow-up studies showed cortical hyperintense lesions on T1-weighted MR images, consistent with cortical laminar necrosis. The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients.