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RT Journal Article
SR Electronic
T1 Quantitative Evaluation of C-Arm CT Cerebral Blood Volume in a Canine Model of Ischemic Stroke
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 353
OP 358
DO 10.3174/ajnr.A2944
VO 33
IS 2
A1 van der Bom, I.M.J.
A1 Mehra, M.
A1 Walvick, R.P.
A1 Chueh, J.-Y.
A1 Gounis, M.J.
YR 2012
UL http://www.ajnr.org/content/33/2/353.abstract
AB BACKGROUND AND PURPOSE: Previous studies have shown the feasibility of assessing qualitative CBV measurements in the angiography suite by using FPD-CBCT systems. We have investigated the correlation of FPD-CBCT CBV lesion volumes to the infarct volume. MATERIALS AND METHODS: Unilateral strokes were created in 7 adult dogs. MR imaging and FPD-CBCT data were obtained after MCA occlusion. FPD-CBCT CBV and ADC maps were generated for all subjects. The animals were sacrificed immediately following the last imaging study to measure infarct volume on histology. The reliability of FPD-CBCT-based lesion volume measurements was compared with those measured histologically by using regression and Bland-Altman analysis. RESULTS: The best correlation (R2 = 0.72) between lesion volumes assessed with FPD-CBCT and histology was established with a threshold of mean healthy CBV − 2.5 × SD. These results were inferior to the correlation of lesion volumes measured with ADC and histology (R2 = 0.99). Bland-Altman analysis showed that the agreement of ADC-derived lesion volumes with histology was superior to the agreement of FPD-CBCT-derived lesion volumes with histology. CONCLUSIONS: We correlated FPD-CBCT measurements of CBV and MR ADC lesion volumes with histologically assessed infarct volume. As expected, ADC is a very accurate and precise method for determining the extent of infarction. FPD-CBCT CBV lesion volumes are correlated to the size of the infarct. Improvement of FPD-CBCT image quality provides an opportunity to establish quantitative CBV measurement in the angiography suite. CTPCT perfusionFPD-CBCTflat panel detector conebeam CTHUHounsfield unitsNSAnumber of signal-intensity averagesR2coefficient of determinationRMSEroot-mean-square errorσSD, standard deviationtlesionlesion thresholdTOFtime-of-flightTTC2,3,5-triphenyltetrazolium chlorideVlesionlesion volume