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RT Journal Article
SR Electronic
T1 Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1343
OP 1348
DO 10.3174/ajnr.A2956
VO 33
IS 7
A1 Jain, R.
A1 Poisson, L.
A1 Narang, J.
A1 Scarpace, L.
A1 Rosenblum, M.L.
A1 Rempel, S.
A1 Mikkelsen, T.
YR 2012
UL http://www.ajnr.org/content/33/7/1343.abstract
AB BACKGROUND AND PURPOSE: Integration of imaging and genomic data is critical for a better understanding of gliomas, particularly considering the increasing focus on the use of imaging biomarkers for patient survival and treatment response. The purpose of this study was to correlate CBV and PS measured by using PCT with the genes regulating angiogenesis in GBM. MATERIALS AND METHODS: Eighteen patients with WHO grade IV gliomas underwent pretreatment PCT and measurement of CBV and PS values from enhancing tumor. Tumor specimens were analyzed by TCGA by using Human Gene Expression Microarrays and were interrogated for correlation between CBV and PS estimates across the genome. We used the GO biologic process pathways for angiogenesis regulation to select genes of interest. RESULTS: We observed expression levels for 92 angiogenesis-associated genes (332 probes), 19 of which had significant correlation with PS and 9 of which had significant correlation with CBV (P &lt; .05). Proangiogenic genes such as TNFRSF1A (PS = 0.53, P = .024), HIF1A (PS = 0.62, P = .0065), KDR (CBV = 0.60, P = .0084; PS = 0.59, P = .0097), TIE1 (CBV = 0.54, P = .022; PS = 0.49, P = .039), and TIE2/TEK (CBV = 0.58, P = .012) showed a significant positive correlation; whereas antiangiogenic genes such as VASH2 (PS = −0.72, P = .00011) showed a significant inverse correlation. CONCLUSIONS: Our findings are provocative, with some of the proangiogenic genes showing a positive correlation and some of the antiangiogenic genes showing an inverse correlation with tumor perfusion parameters, suggesting a molecular basis for these imaging biomarkers; however, this should be confirmed in a larger patient population. FGF2fibroblast growth factor 2GBMglioblastomaGOGene OntologyMMP1matrix metallopeptidase 1 (interstitial collagenase)PCTperfusion CTPSpermeability surface area productTCGAThe Cancer Genome AtlasTNFtumor necrosis factorVASH1vasohibin 1VEvascular epitheliumVEGFvascular endothelial growth factorWHOWorld Health Organization