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RT Journal Article
SR Electronic
T1 GABA-Based Evaluation of Neurologic Conditions: MR Spectroscopy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 259
OP 265
DO 10.3174/ajnr.A2902
VO 34
IS 2
A1 Levy, L.M.
A1 Degnan, A.J.
YR 2013
UL http://www.ajnr.org/content/34/2/259.abstract
AB SUMMARY: GABA serves as a major neurotransmitter of the brain and functions mainly to inhibit neural excitatory activity. Disruption of the GABAergic processes appears to occur in various neurologic and psychiatric conditions, including epilepsy, mood disorders, motor disorders such as focal dystonia and stiff-person syndrome, sleep disorders, neuroplasticity, and drug and alcohol dependence. These concentration differences may be ascertained by using MR spectroscopy to provide information on the concentration of different metabolites. This review briefly discusses advances in MR spectroscopy methods and explores the application of this technique to detect changes in GABA due to disease processes and medication-induced effects. AEDantiepileptic drugGABAγ-aminobutyric acidGABAARγ-amino butyric acid A receptorGABABRγ-amino butyric acid B receptorGABA-TGABA transaminaseGADglutamic acid decarboxylaseJ-PRESSa combined 2D point-resolved spectroscopy sequenceSSRIselective serotonin reuptake inhibitor