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RT Journal Article
SR Electronic
T1 Central Nervous System Involvement in Adults with Epidemic Hemolytic Uremic Syndrome
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1016
OP 1021
DO 10.3174/ajnr.A3336
VO 34
IS 5
A1 Wengenroth, M.
A1 Hoeltje, J.
A1 Repenthin, J.
A1 Meyer, T.N.
A1 Bonk, F.
A1 Becker, H.
A1 Faiss, S.
A1 Stammel, O.
A1 Urban, P.P.
A1 Bruening, R.
YR 2013
UL http://www.ajnr.org/content/34/5/1016.abstract
AB SUMMARY: Hemolytic uremic syndrome is a multisystem disorder that is caused by infection with Shiga-toxin-producing Escherichia coli. HUS affects mainly children and is rare among adults. This retrospective case series analyzes clinical signs and MR imaging findings of 11 adult patients with HUS associated nervous system involvement during the epidemic EHEC outbreak in northern Europe with its epicenter in Hamburg in May 2011. The most prevalent imaging finding was symmetric pointy vasogenic edema of the brain stem in the acute and subacute phases of the disease (n = 5). One patient exhibited additional symmetric mesiotemporal signal changes mimicking limbic encephalitis. Two patients developed subcortical patchy lesions, and 4 subjects did not present with any signal changes. Remarkably, territorial ischemia, signs of hemorrhage, or blood-brain barrier disruption have not been detected. While brain stem lesions were transient and normalized with clinical recovery, supratentorial lesions did not resolve completely at 2-month follow-up examination. EHECenterohemorrhagic Escherichia coliHUShemolytic uremic syndromePRESposterior reversible encephalopathy syndromeSTECShiga toxin–producing E coli