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PT  - JOURNAL ARTICLE
AU  - Yeom, K.W.
AU  - Lober, R.M.
AU  - Barnes, P.D.
AU  - Campen, C.J.
TI  - Reduced Cerebral Arterial Spin-Labeled Perfusion in Children with Neurofibromatosis Type 1
AID  - 10.3174/ajnr.A3649
DP  - 2013 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1823--1828
VI  - 34
IP  - 9
4099  - http://www.ajnr.org/content/34/9/1823.short
4100  - http://www.ajnr.org/content/34/9/1823.full
SO  - Am. J. Neuroradiol.2013 Sep 01; 34
AB  - BACKGROUND AND PURPOSE: Neurofibromatosis type 1 is associated with increased risk for stroke, cerebral vasculopathy, and neurocognitive deficits, but underlying hemodynamic changes in asymptomatic children remain poorly understood. We hypothesized that children with neurofibromatosis type 1 have decreased cerebral blood flow. MATERIALS AND METHODS: Arterial spin-labeled CBF was measured in 14 children with neurofibromatosis type 1 (median age, 9.7 years; mean, 10.2 years; range, 22 months to 18 years) and compared with age-matched control subjects on 3T MR imaging. Three-dimensional pseudocontinuous spin-echo arterial spin-labeled technique was used. Measurements were obtained at cortical gray matter of bilateral cerebral hemispheres and centrum semiovale by use of the ROI method. Comparison by Mann-Whitney test was used, with Bonferroni-adjusted P values ≤.004 judged as significant. RESULTS: We identified 7 of 12 areas with significantly diminished arterial spin-labeled CBF in patients with neurofibromatosis type 1 compared with control subjects. These areas included the anterior cingulate gyrus (P = .001), medial frontal cortex (P = .004), centrum semiovale (P = .004), temporo-occipital cortex (P = .002), thalamus (P = .001), posterior cingulate gyrus (P = .002), and occipital cortex (P = .001). Among patients with neurofibromatosis type 1, there were no significant differences in these regions on the basis of the presence of neurofibromatosis type 1 spots or neurocognitive deficits. CONCLUSIONS: Reduced cerebral perfusion was seen in children with neurofibromatosis type 1, particularly in the posterior circulation and the vascular borderzones of the middle and posterior cerebral arteries. ASLarterial spin-labeledNF-1neurofibromatosis type 1UBOunidentified bright object