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PT  - JOURNAL ARTICLE
AU  - Zivadinov, R.
AU  - Bergsland, N.
AU  - Dolezal, O.
AU  - Hussein, S.
AU  - Seidl, Z.
AU  - Dwyer, M.G.
AU  - Vaneckova, M.
AU  - Krasensky, J.
AU  - Potts, J.A.
AU  - Kalincik, T.
AU  - Havrdová, E.
AU  - Horáková, D.
TI  - Evolution of Cortical and Thalamus Atrophy and Disability Progression in Early Relapsing-Remitting MS during 5 Years
AID  - 10.3174/ajnr.A3503
DP  - 2013 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1931--1939
VI  - 34
IP  - 10
4099  - http://www.ajnr.org/content/34/10/1931.short
4100  - http://www.ajnr.org/content/34/10/1931.full
SO  - Am. J. Neuroradiol.2013 Oct 01; 34
AB  - BACKGROUND AND PURPOSE: Pathologic changes in GM have an important role in MS. We investigated the association between SDGM and cortical volume changes and disability progression in early RRMS. MATERIALS AND METHODS: One hundred eighty patients with RRMS had clinical assessment during 5 years and were divided into those with or without SDP at 5 years by the usual definition in treatment trials. The number of available MR imaging scans at various time points was the following: at baseline, 178; and at 6 months, 172; at 12 months, 175; at 24 months, 155; at 36 months, 160; at 48 months, 158; and at 60 months, 162, respectively. Longitudinal changes in cortical, GM, and WM volume were calculated by using the direct method. RESULTS: At 5 years, 90 patients with RRMS experienced SDP and 90 had stable disease. At baseline, patients with SDP had longer disease duration, greater T2-lesion volume, and smaller whole-brain, WM, cortical, and SDGM volume (P &amp;lt; .01). At 5 years, patients with SDP had significantly greater percentage decreases from baseline compared with those without SDP in the volume of the whole brain (P &amp;lt; .0001), cortex (P = .001), GM (P = .003), and thalamus (P = .01). In patients who developed SDP at 5 years and those who did not, mixed-effect models, adjusted for age, disease duration, and change of the treatment status, showed significant interactions between SDP status at 5 years and changes with time in whole-brain, cortical, lateral ventricle (all P &amp;lt; .001), thalamus (P = .006), and total SDGM (P = .0095) volume. CONCLUSIONS: SDP is associated with progression of cortical, central, and thalamic atrophy in early RRMS during 5 years. ASAAvonex-Steroid-AzathioprineEDSSExpanded Disability Status ScaleGMgray matterRRrelapsing-remittingSDGMsubcortical deep gray matterSDPsustained disability progressionSIENAstructural image evaluation with normalization of atrophy.