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RT Journal Article
SR Electronic
T1 Abnormal Functional Network Connectivity among Resting-State Networks in Children with Frontal Lobe Epilepsy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2386
OP 2392
DO 10.3174/ajnr.A3608
VO 34
IS 12
A1 Widjaja, E.
A1 Zamyadi, M.
A1 Raybaud, C.
A1 Snead, O.C.
A1 Smith, M.L.
YR 2013
UL http://www.ajnr.org/content/34/12/2386.abstract
AB BACKGROUND AND PURPOSE: Epilepsy is considered a disorder of neural networks. The aims of this study were to assess functional connectivity within resting-state networks and functional network connectivity across resting-state networks by use of resting-state fMRI in children with frontal lobe epilepsy and to relate changes in resting-state networks with neuropsychological function. MATERIALS AND METHODS: Fifteen patients with frontal lobe epilepsy and normal MR imaging and 14 healthy control subjects were recruited. Spatial independent component analysis was used to identify the resting-state networks, including frontal, attention, default mode network, sensorimotor, visual, and auditory networks. The Z-maps of resting-state networks were compared between patients and control subjects. The relation between abnormal connectivity and neuropsychological function was assessed. Correlations from all pair-wise combinations of independent components were performed for each group and compared between groups. RESULTS: The frontal network was the only network that showed reduced connectivity in patients relative to control subjects. The remaining 5 networks demonstrated both reduced and increased functional connectivity within resting-state networks in patients. There was a weak association between connectivity in frontal network and executive function (P = .029) and a significant association between sensorimotor network and fine motor function (P = .004). Control subjects had 79 pair-wise independent components that showed significant temporal coherence across all resting-state networks except for default mode network–auditory network. Patients had 66 pairs of independent components that showed significant temporal coherence across all resting-state networks. Group comparison showed reduced functional network connectivity between default mode network–attention, frontal-sensorimotor, and frontal-visual networks and increased functional network connectivity between frontal-attention, default mode network–sensorimotor, and frontal-visual networks in patients relative to control subjects. CONCLUSIONS: We found abnormal functional connectivity within and across resting-state networks in children with frontal lobe epilepsy. Impairment in functional connectivity was associated with impaired neuropsychological function. FLEfrontal lobe epilepsyICindependent componentICAindependent component analysisDMNdefault mode networkRSNresting-state networkTLEtemporal lobe epilepsyFNCfunctional network connectivityDKEFSDelis-Kaplan Executive Function System