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PT  - JOURNAL ARTICLE
AU  - Zagzag, David
AU  - Goldenberg, Marvin
AU  - Brem, Steven
TI  - Angiogenesis and Blood-Brain Barrier Breakdown Modulate CT Contrast Enhancement: An Experimental Study in a Rabbit Brain-Tumor Model
DP  - 1989 May 01
TA  - American Journal of Neuroradiology
PG  - 529--534
VI  - 10
IP  - 3
4099  - http://www.ajnr.org/content/10/3/529.short
4100  - http://www.ajnr.org/content/10/3/529.full
SO  - Am. J. Neuroradiol.1989 May 01; 10
AB  - Because of the crucial role played by tumor neovascularization in contrast enhancement, we studied the CT imaging findings in a transplantable rabbit brain tumor, the VX2 carcinoma that induces angiogenesis and the breakdown of blood-brain barrier associated with contrast enhancement. Tumor detection by contrast enhancement followed the peak of angiogenesis. Inhibition of angiogenesis, by copper depletion and penicillamine, led to avascular tumors that lack contrast enhancement. Furthermore, there was no contrast enhancement in brain adjacent to the tumor of normocupremic rabbits or within the hypocupremic tumor, despite the breakdown of the blood-brain barrier, without the concomitant presence of angiogenesis. We conclude that contrast enhancement of intracranial tumors is dependent primarily on the proliferation of the microvasculature.