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PT  - JOURNAL ARTICLE
AU  - Rogg, Jeffrey
AU  - Rutigliano, Michael
AU  - Yonas, Howard
AU  - Johnson, David W.
AU  - Pentheny, Susan
AU  - Latchaw, Richard E.
TI  - The Acetazolamide Challenge: Imaging Techniques Designed to Evaluate Cerebral Blood Flow Reserve
DP  - 1989 Jul 01
TA  - American Journal of Neuroradiology
PG  - 803--810
VI  - 10
IP  - 4
4099  - http://www.ajnr.org/content/10/4/803.short
4100  - http://www.ajnr.org/content/10/4/803.full
SO  - Am. J. Neuroradiol.1989 Jul 01; 10
AB  - Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status. The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.