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RT Journal Article
SR Electronic
T1 The Acetazolamide Challenge: Imaging Techniques Designed to Evaluate Cerebral Blood Flow Reserve
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 803
OP 810
VO 10
IS 4
A1 Rogg, Jeffrey
A1 Rutigliano, Michael
A1 Yonas, Howard
A1 Johnson, David W.
A1 Pentheny, Susan
A1 Latchaw, Richard E.
YR 1989
UL http://www.ajnr.org/content/10/4/803.abstract
AB Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status. The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.