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RT Journal Article
SR Electronic
T1 PET Approaches for Diagnosis of Dementia
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2030
OP 2038
DO 10.3174/ajnr.A3695
VO 35
IS 11
A1 Ishii, K.
YR 2014
UL http://www.ajnr.org/content/35/11/2030.abstract
AB SUMMARY: There is increasing use of neuroimaging modalities, including PET, for diagnosing dementia. For example, FDG-PET demonstrates hypometabolic regions in the posterior cingulate gyri, precuneus, and parietotemporal association cortices, while amyloid PET indicates amyloid deposition in Alzheimer disease and mild cognitive impairment due to Alzheimer disease. Furthermore, the use of combination PET with structural MR imaging can improve the diagnostic accuracy of dementia. In other neurodegenerative dementias, each disease exhibits a specific metabolic reduction pattern. In dementia with Lewy bodies, occipital glucose metabolism is decreased, while in frontotemporal dementia, frontal and anterior temporal metabolism is predominantly decreased. These FDG-PET findings and positive or negative amyloid deposits are important biomarkers for various neurodegenerative dementias. Aβamyloid β peptideADAlzheimer diseaseAPOEapolipoprotein ECBDcorticobasal degenerationDLBdementia with Lewy bodiesFTDfrontotemporal dementiaMCImild cognitive impairmentPDParkinson diseasePiBPittsburgh compound-BPSPprogressive supranuclear palsyVBMvoxel-based morphometry