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PT  - JOURNAL ARTICLE
AU  - Tanweer, O.
AU  - Raz, E.
AU  - Brunswick, A.
AU  - Zumofen, D.
AU  - Shapiro, M.
AU  - Riina, H.A.
AU  - Fouladvand, M.
AU  - Becske, T.
AU  - Nelson, P.K.
TI  - Cavernous Carotid Aneurysms in the Era of Flow Diversion: A Need to Revisit Treatment Paradigms
AID  - 10.3174/ajnr.A4081
DP  - 2014 Dec 01
TA  - American Journal of Neuroradiology
PG  - 2334--2340
VI  - 35
IP  - 12
4099  - http://www.ajnr.org/content/35/12/2334.short
4100  - http://www.ajnr.org/content/35/12/2334.full
SO  - Am. J. Neuroradiol.2014 Dec 01; 35
AB  - BACKGROUND AND PURPOSE: Recent techniques of endoluminal reconstruction with flow-diverting stents have not been incorporated into treatment algorithms for cavernous carotid aneurysms. This study examines the authors&#039; institutional experience and a systematic review of the literature for outcomes and complications using the Pipeline Embolization Device in unruptured cavernous carotid aneurysms. MATERIALS AND METHODS: A retrospective search for cavernous carotid aneurysms from a prospectively collected data base of aneurysms treated with the Pipeline Embolization Device at our institution was performed. Baseline demographic, clinical, and laboratory values; intrainterventional data; and data at all follow-up visits were collected. A systematic review of the literature for complication data was performed with inquiries sent when clarification of data was needed. RESULTS: Forty-three cavernous carotid aneurysms were included in the study. Our mean radiographic follow-up was 2.05 years. On last follow-up, 88.4% of the aneurysms treated had complete or near-complete occlusion. Aneurysm complete or near-complete occlusion rates at 6 months, 12 months, and 36 months were 81.4%, 89.7%, and 100%, respectively. Of patients with neuro-ophthalmologic deficits on presentation, 84.2% had improvement in their visual symptoms. Overall, we had a 0% mortality rate and a 2.3% major neurologic complication rate. Our systematic review of the literature yielded 227 cavernous carotid aneurysms treated with the Pipeline Embolization Device with mortality and morbidity rates of 0.4% and 3.1%, respectively. CONCLUSIONS: Endoluminal reconstruction with flow diversion for large unruptured cavernous carotid aneurysms can yield high efficacy with low complications. Further long-term data will be helpful in assessing the durability of the cure; however, we advocate a revisiting of current management paradigms for cavernous carotid aneurysms. CCAcavernous carotid aneurysmPEDPipeline Embolization Device