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PT  - JOURNAL ARTICLE
AU  - Wakhloo, A.K.
AU  - Lylyk, P.
AU  - de Vries, J.
AU  - Taschner, C.
AU  - Lundquist, J.
AU  - Biondi, A.
AU  - Hartmann, M.
AU  - Szikora, I.
AU  - Pierot, L.
AU  - Sakai, N.
AU  - Imamura, H.
AU  - Sourour, N.
AU  - Rennie, I.
AU  - Skalej, M.
AU  - Beuing, O.
AU  - Bonafé, A.
AU  - Mery, F.
AU  - Turjman, F.
AU  - Brouwer, P.
AU  - Boccardi, E.
AU  - Valvassori, L.
AU  - Derakhshani, S.
AU  - Litzenberg, M.W.
AU  - Gounis, M.J.
AU - for the Surpass Study Group
TI  - Surpass Flow Diverter in the Treatment of Intracranial Aneurysms: A Prospective Multicenter Study
AID  - 10.3174/ajnr.A4078
DP  - 2015 Jan 01
TA  - American Journal of Neuroradiology
PG  - 98--107
VI  - 36
IP  - 1
4099  - http://www.ajnr.org/content/36/1/98.short
4100  - http://www.ajnr.org/content/36/1/98.full
SO  - Am. J. Neuroradiol.2015 Jan 01; 36
AB  - BACKGROUND AND PURPOSE: Incomplete occlusion and recanalization of large and wide-neck brain aneurysms treated by endovascular therapy remains a challenge. We present preliminary clinical and angiographic results of an experimentally optimized Surpass flow diverter for treatment of intracranial aneurysms in a prospective, multicenter, nonrandomized, single-arm study. MATERIALS AND METHODS: At 24 centers, 165 patients with 190 intracranial aneurysms of the anterior and posterior circulations were enrolled. The primary efficacy end point was the percentage of intracranial aneurysms with 100% occlusion on 6-month DSA. The primary safety end point was neurologic death and any stroke through a minimum follow-up of 6 months. RESULTS: Successful flow-diverter delivery was achieved in 161 patients with 186 aneurysms (98%); the mean number of devices used per aneurysm was 1.05. Clinical follow-up (median, 6 months) of 150 patients (93.2%), showed that the primary safety end point occurred in 18 subjects. Permanent neurologic morbidity and mortality were 6% and 2.7%, respectively. Morbidity occurred in 4% and 7.4% of patients treated for aneurysms of the anterior and posterior circulation, respectively. Neurologic death during follow-up was observed in 1.6% and 7.4% of patients with treated intracranial aneurysms of the anterior and posterior circulation, respectively. Ischemic stroke at ≤30 days, SAH at ≤7 days, and intraparenchymal hemorrhage at ≤7 days were encountered in 3.7%, 2.5%, and 2.5% of subjects, respectively. No disabling ischemic strokes at &amp;gt;30 days or SAH at &amp;gt;7 days occurred. New or worsening cranial nerve deficit was observed in 2.7%. Follow-up angiography available in 158 (86.8%) intracranial aneurysms showed 100% occlusion in 75%. CONCLUSIONS: Clinical outcomes of the Surpass flow diverter in the treatment of intracranial aneurysms show a safety profile that is comparable with that of stent-assisted coil embolization. Angiographic results showed a high rate of intracranial aneurysm occlusion. EVTendovascular treatmentFDflow diverterPUFSPipeline Embolization Device for Uncoilable or Failed Aneurysms