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PT  - JOURNAL ARTICLE
AU  - Raji, C.A.
AU  - Eyre, H.
AU  - Wei, S.H.
AU  - Bredesen, D.E.
AU  - Moylan, S.
AU  - Law, M.
AU  - Small, G.
AU  - Thompson, P.M.
AU  - Friedlander, R.M.
AU  - Silverman, D.H.
AU  - Baune, B.T.
AU  - Hoang, T.A.
AU  - Salamon, N.
AU  - Toga, A.W.
AU  - Vernooij, M.W.
TI  - Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
AID  - 10.3174/ajnr.A4409
DP  - 2015 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1803--1809
VI  - 36
IP  - 10
4099  - http://www.ajnr.org/content/36/10/1803.short
4100  - http://www.ajnr.org/content/36/10/1803.full
SO  - Am. J. Neuroradiol.2015 Oct 01; 36
AB  - SUMMARY: Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.ADAlzheimer diseaseAPOEApolipoprotein EBMIbody mass indexMCImild cognitive impairment