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RT Journal Article
SR Electronic
T1 Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [<sup>18</sup>F] Florbetapir PET Brain Scan Interpretation
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1237
OP 1244
DO 10.3174/ajnr.A4281
VO 36
IS 7
A1 Nayate, A.P.
A1 Dubroff, J.G.
A1 Schmitt, J.E.
A1 Nasrallah, I.
A1 Kishore, R.
A1 Mankoff, D.
A1 Pryma, D.A.
YR 2015
UL http://www.ajnr.org/content/36/7/1237.abstract
AB BACKGROUND AND PURPOSE: Fluorine-18 florbetapir is a recently developed β-amyloid plaque positron-emission tomography imaging agent with high sensitivity, specificity, and accuracy in the detection of moderate-to-frequent cerebral cortical β-amyloid plaque. However, the FDA has expressed concerns about the consistency of interpretation of [18F] florbetapir PET brain scans. We hypothesized that incorporating automated cerebral-to-whole-cerebellar standardized uptake value ratios into [18F] florbetapir PET brain scan interpretation would reduce this interreader variability.MATERIALS AND METHODS: This randomized, blinded-reader study used previously acquired [18F] florbetapir scans from 30 anonymized patients who were enrolled in the Alzheimer's Disease Neuroimaging Initiative 2. In 4 separate, blinded-reading sessions, 5 readers classified 30 cases as positive or negative for significant β-amyloid deposition either qualitatively alone or qualitatively with additional adjunct software that determined standardized uptake value ratios. A κ coefficient was used to calculate interreader agreement with and without the use of standardized uptake value ratios.RESULTS: There was complete interreader agreement on 20/30 cases of [18F] florbetapir PET brain scans by using qualitative interpretation and on 27/30 scans interpreted with the adjunct use of standardized uptake value ratios. The κ coefficient for the studies read with standardized uptake value ratios (0.92) was significantly higher compared with the qualitatively read studies (0.69, P = .006).CONCLUSIONS: Use of standardized uptake value ratios improves interreader agreement in the interpretation of [18F] florbetapir images.ADAlzheimer diseaseADNIAlzheimer's Disease Neuroimaging InitiativeEADearly ADEMCIearly mild cognitive impairmentLMCIlate mild cognitive impairmentSUVrstandardized uptake value ratios