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PT  - JOURNAL ARTICLE
AU  - Su, L.
AU  - An, J.
AU  - Ma, Q.
AU  - Qiu, S.
AU  - Hu, D.
TI  - Influence of Resting-State Network on Lateralization of Functional Connectivity in Mesial Temporal Lobe Epilepsy
AID  - 10.3174/ajnr.A4346
DP  - 2015 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1479--1487
VI  - 36
IP  - 8
4099  - http://www.ajnr.org/content/36/8/1479.short
4100  - http://www.ajnr.org/content/36/8/1479.full
SO  - Am. J. Neuroradiol.2015 Aug 01; 36
AB  - BACKGROUND AND PURPOSE: Although most studies on epilepsy have focused on the epileptogenic zone, epilepsy is a system-level disease characterized by aberrant neuronal synchronization among groups of neurons. Increasingly, studies have indicated that mesial temporal lobe epilepsy may be a network-level disease; however, few investigations have examined resting-state functional connectivity of the entire brain, particularly in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. This study primarily investigated whole-brain resting-state functional connectivity abnormality in patients with mesial temporal lobe epilepsy and right hippocampal sclerosis during the interictal period.MATERIALS AND METHODS: We investigated resting-state functional connectivity of 21 patients with mesial temporal lobe epilepsy with right hippocampal sclerosis and 21 neurologically healthy controls. A multivariate pattern analysis was used to identify the functional connections that most clearly differentiated patients with mesial temporal lobe epilepsy with right hippocampal sclerosis from controls.RESULTS: Discriminative analysis of functional connections indicated that the patients with mesial temporal lobe epilepsy with right hippocampal sclerosis exhibited decreased resting-state functional connectivity within the right hemisphere and increased resting-state functional connectivity within the left hemisphere. Resting-state network analysis suggested that the internetwork connections typically obey the hemispheric lateralization trend and most of the functional connections that disturb the lateralization trend are the intranetwork ones.CONCLUSIONS: The current findings suggest that weakening of the resting-state functional connectivity associated with the right hemisphere appears to strengthen resting-state functional connectivity on the contralateral side, which may be related to the seizure-induced damage and underlying compensatory mechanisms. Resting-state network–based analysis indicated that the compensatory mechanism among different resting-state networks may disturb the hemispheric lateralization.DMNdefault-mode networkFCfunctional connectivity or connectionHShippocampal sclerosismTLEmesial temporal lobe epilepsyR-mTLEmesial temporal lobe epilepsy with right hippocampal sclerosisRSresting-stateRSNresting-state networkTLEtemporal lobe epilepsy