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PT  - JOURNAL ARTICLE
AU  - McCoy, D.B.
AU  - Talbott, J.F.
AU  - Wilson, Michael
AU  - Mamlouk, M.D.
AU  - Cohen-Adad, J.
AU  - Wilson, Mark
AU  - Narvid, J.
TI  - MRI Atlas-Based Measurement of Spinal Cord Injury Predicts Outcome in Acute Flaccid Myelitis
AID  - 10.3174/ajnr.A5044
DP  - 2017 Feb 01
TA  - American Journal of Neuroradiology
PG  - 410--417
VI  - 38
IP  - 2
4099  - http://www.ajnr.org/content/38/2/410.short
4100  - http://www.ajnr.org/content/38/2/410.full
SO  - Am. J. Neuroradiol.2017 Feb 01; 38
AB  - BACKGROUND AND PURPOSE: Recent advances in spinal cord imaging analysis have led to the development of a robust anatomic template and atlas incorporated into an open-source platform referred to as the Spinal Cord Toolbox. Using the Spinal Cord Toolbox, we sought to correlate measures of GM, WM, and cross-sectional area pathology on T2 MR imaging with motor disability in patients with acute flaccid myelitis.MATERIALS AND METHODS: Spinal cord imaging for 9 patients with acute flaccid myelitis was analyzed by using the Spinal Cord Toolbox. A semiautomated pipeline using the Spinal Cord Toolbox measured lesion involvement in GM, WM, and total spinal cord cross-sectional area. Proportions of GM, WM, and cross-sectional area affected by T2 hyperintensity were calculated across 3 ROIs: 1) center axial section of lesion; 2) full lesion segment; and 3) full cord atlas volume. Spearman rank order correlation was calculated to compare MR metrics with clinical measures of disability.RESULTS: Proportion of GM metrics at the center axial section significantly correlated with measures of motor impairment upon admission (r [9] = −0.78; P = .014) and at 3-month follow-up (r [9] = −0.66; P = .05). Further, proportion of GM extracted across the full lesion segment significantly correlated with initial motor impairment (r [9] = −0.74, P = .024). No significant correlation was found for proportion of WM or proportion of cross-sectional area with clinical disability.CONCLUSIONS: Atlas-based measures of proportion of GM T2 signal abnormality measured on a single axial MR imaging section and across the full lesion segment correlate with motor impairment and outcome in patients with acute flaccid myelitis. This is the first atlas-based study to correlate clinical outcomes with segmented measures of T2 signal abnormality in the spinal cord.%CSAproportion of cross-sectional area%GMproportion of gray matter%WMproportion of white matterAFMacute flaccid myelitisEVenterovirusMRCMedical Research CouncilSCspinal cordSCTSpinal Cord Toolbox