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RT Journal Article
SR Electronic
T1 A Novel Flexible, Retrievable Endovascular Stent System for Small-Vessel Anatomy: Preliminary <em>In Vivo</em> Data
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 862
OP 868
VO 26
IS 4
A1 Doerfler, Arnd
A1 Becker, Wolfgang P. H.
A1 Wanke, Isabel
A1 Goericke, Sophia L.
A1 Mueller, K. M.
A1 Blechschmid, Nina
A1 Flesser, Achim
A1 Monstadt, Hermann
A1 Forsting, Michael
YR 2005
UL http://www.ajnr.org/content/26/4/862.abstract
AB BACKGROUND AND PURPOSE: This study assessed the in vivo delivery, retrievability, short-term patency, and cellular response to a new flexible endovascular stent system in a rabbit model. The stent is designed for delivery through a microcatheter and is fully retrievable with electrolytic detachment from a delivery wire.METHODS: We successfully deployed nine stents (range of sizes, 2.5–4 mm diameter, 15–35 mm length) in six straight (carotid) and three angled (subclavian) arteries of six Chinchilla Bastard rabbits. Serial imaging was performed by using intravenous digital subtraction angiography (IVDSA), contrast-enhanced MR angiography (CEMRA), time-of-flight MR angiography (TOF), and CT-angiography 3 days and 4 weeks after stent deployment. Subjects were euthenized after 4 weeks (n = 5), and stents were removed for histologic analysis.RESULTS: Stent deployment was feasible in all cases. After initial deployment, all stents could be fully retrieved within the microcatheter. The detachment zone and the distal stent marker were easily visible under fluoroscopy, and final detachment occurred reliably in all cases. We observed no procedural complications. Noninvasive imaging by using IVDSA, MR angiography, and CT angiography was feasible in this stent system and demonstrated all arteries patent and not narrowed at 3 days and 4 weeks, findings that were confirmed by histologic analysis.CONCLUSION: This electrolytically detachable stent is promising as a treatment for intracranial arteries, because it can be delivered through microcatheters small enough for intracranial navigation. It is fully retrievable, thus providing greater control than currently available stents. Noninvasive imaging by using IVDSA, MR angiography, and CT angiography is feasible in this stent system and may be useful for follow-up. Further long-term data are needed.